Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

孟德尔随机化生物疾病全基因组关联研究遗传学体力活动久坐的生活习惯基因生物信息学内科学内分泌学单核苷酸多态性肥胖基因型医学物理医学与康复遗传变异

作者

Zhe Wang,Andrew Emmerich,Nicolas J. Pillon,Timothy M. Moore,Daiane Hemerich,Marilyn C. Cornelis,Eugenia Mazzaferro,Siacia Broos,Tarunveer S. Ahluwalia,Traci M. Bartz,Amy R. Bentley,Lawrence F. Bielak,Michael Chong,Audrey Y. Chu,Diane J. Berry,Rajkumar Dorajoo,Nicole Dueker,Elisa Kasbohm,Bjarke Feenstra,Mary F. Feitosa,Christian Gieger,Mariaelisa Graff,Christopher P. Nelson,Toomas Haller,Fernando Pires Hartwig,David A. Hillis,Ville Huikari,Nancy L. Heard‐Costa,Christina Holzapfel,Anne Jackson,Åsa Johansson,Anja Moltke Jørgensen,Marika Kaakinen,Robert Karlsson,Kathleen F. Kerr,Boram Kim,Chantal M. Koolhaas,Zoltán Kutalik,Vasiliki Lagou,Penelope A. Lind,Mattias Lorentzon,Leo‐Pekka Lyytikäinen,Massimo Mangino,Christoph Metzendorf,Kristine R. Monroe,Alexander Pacolet,Louis Pérusse,René Pool,Rebecca C. Richmond,Natalia V. Rivera,Sébastien Robiou-du-Pont,Katharina E. Schraut,Christina‐Alexandra Schulz,Heather M. Stringham,Toshiko Tanaka,Alexander Teumer,Yung‐Po Liaw,Peter J. van der Most,Mathias Vanmunster,Frank J.A. van Rooij,Jana V. van Vliet‐Ostaptchouk,Xiaoshuai Zhang,Jinghua Zhao,Wei Zhao,Zhanna Balkhiyarova,Marie Balslev‐Harder,Sebastian E. Baumeister,John L. Hopper,John Blangero,Dorret I. Boomsma,Sören Brage,Peter S. Braund,Jennifer A. Brody,Marcel Bruinenberg,Ulf Ekelund,Yongmei Liu,John W. Cole,Francis S. Collins,L. Adrienne Cupples,Tõnu Esko,Stefan Enroth,Jessica D. Faul,Lindsay Fernández‐Rhodes,Alison E. Fohner,Oscar H. Franco,Tessel E. Galesloot,Scott D. Gordon,Niels Grarup,Catharina A. Hartman,Peter K. Joshi,Jennie Hui,Thomas Benzing,Russell Jago,Anthony James,Peter K. Joshi,Taeyeong Jung,Mika Kähönen,Tuomas O. Kilpeläinen,Woon‐Puay Koh,Ivana Kolčić,Peter Kraft,Claudia Langenberg,Lenore J. Launer,Aihua Li,Allan Linneberg,Jian’an Luan,Pedro Marques‐Vidal,Sarah E. Medland,Yuri Milaneschi,Arden Moscati,Bill Musk,Christopher P. Nelson,Ilja M. Nolte,Nancy L. Pedersen,Annette Peters,Patricia A. Peyser,Christopher Power,Olli T. Raitakari,Mägi Reedik,Alexander P. Reiner,Paul W. Franks,Igor Rudan,Kathleen A. Ryan,Mark A. Sarzynski,Laura J. Scott,Robert A. Scott,Stephen Sidney,Kristín Siggeirsdóttir,Albert Hofman,Jennifer A. Smith,Emily Sonestedt,Marin Strøm,E Shyong Tai,Koon Teo,Barbara Thorand,Anke Tönjes,Angelo Tremblay,André G. Uitterlinden,Jagadish Vangipurapu,Natasja M. van Schoor,Uwe Völker,Gonneke Willemsen,Kayleen Williams,Quenna Wong,Huichun Xu,Kristin L. Young,Jian‐Min Yuan,M. Carola Zillikens,Alan B. Zonderman,Adam Ameur,Stefania Bandinelli,Joshua C. Bis,Michael Boehnke,Claude Bouchard,Daniel I. Chasman,George Davey Smith,Eco J. C. de Geus,Louise Deldicque,Marcus Dörr,Michele K. Evans,Luigi Ferrucci,Myriam Fornage,Caroline Hayward,Theodore Garland,Vilmundur Guðnason,Ulf Gyllensten,Torben Hansen,Caroline Hayward,Bernardo Lessa Horta,Elina Hyppönen,Marjo‐Riitta Järvelin,W. Craig Johnson,Sharon L. R. Kardia,Lambertus A. Kiemeney,Markku Laakso,Claudia Langenberg,Terho Lehtimäki,Loı̈c Le Marchand,Behrooz Z. Alizadeh,Wolfgang Köenig,Lude Franke,Morris A. Swertz,Cisca Wijmenga,Pim van der Harst,Gerjan Navis,André G. Uitterlinden,Bruce H. R. Wolffenbuttel,Patrik K. E. Magnusson,Nicholas G. Martin,Mads Melbye,Andres Metspalu,David Meyre,Kari E. North,Claes Ohlsson,Albertine J. Oldehinkel,Marju Orho–Melander,Guillaume Paré,Taesung Park,Oluf Pedersen,Brenda W.J.H. Penninx,Tune H. Pers,Ozren Polašek,Inga Prokopenko,Charles N. Rotimi,Nilesh J. Samani,Xueling Sim,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Nicholas J. Timpson,Rob M. van Dam,Nathalie van der Velde,Cornelia M. van Duijn,Péter Vollenweider,Henry Völzke,Trudy Voortman,Gérard Waeber,Nicholas J. Wareham,David R. Weir,Heinz‐Erich Wichmann,James F. Wilson,Andrea L. Hevener,Anna Krook,Juleen R. Zierath,Martine Thomis,Ruth J. F. Loos,Marcel den Hoed

出处

期刊：Nature Genetics [Springer Nature]
日期：2022-09-01 卷期号：54 (9): 1332-1344 被引量：95

标识

DOI：10.1038/s41588-022-01165-1

摘要

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II

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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

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