已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Liver biopsy-based validation, confirmation and comparison of the diagnostic performance of established and novel non-invasive steatotic liver disease indexes: Results from a large multi-center study

脂肪性肝炎 脂肪肝 肝病学 医学 肝活检 内科学 脂肪变性 纤维化 胃肠病学 肝病 非酒精性脂肪肝 活检 病理 疾病
作者
Matina Kouvari,Laura Valenzuela‐Vallejo,Valentina Guatibonza-García,Stergios A. Pοlyzos,Yixiang Deng,Michail Kokkorakis,Melih Agraz,Sophia C. Mylonakis,Angeliki Katsarou,Ornella Verrastro,Georgios Markakis,Mohammed Eslam,George Papatheodoridis,Jacob George,Geltrude Mingrone,Christos S. Mantzoros
出处
期刊:Metabolism-clinical and Experimental [Elsevier BV]
卷期号:147: 155666-155666 被引量:43
标识
DOI:10.1016/j.metabol.2023.155666
摘要

Non-invasive tools (NIT) for metabolic-dysfunction associated liver disease (MASLD) screening or diagnosis need to be thoroughly validated using liver biopsies.To externally validate NITs designed to differentiate the presence or absence of liver steatosis as well as more advanced disease stages, to confirm fully validated indexes (n = 7 NITs), to fully validate partially validated indexes (n = 5 NITs), and to validate for the first time one new index (n = 1 NIT).This is a multi-center study from two Gastroenterology-Hepatology Departments (Greece and Australia) and one Bariatric-Metabolic Surgery Department (Italy). Overall, n = 455 serum samples of patients with biopsy-proven MASLD (n = 374, including 237 patients with metabolic-dysfunction associated steatohepatitis (MASH)) and Controls (n = 81) were recruited. A complete validation analysis was performed to differentiate the presence of MASLD vs. Controls, MASH vs. metabolic-dysfunction associated steatotic liver (MASL), histological features of MASH, and fibrosis stages.The index of NASH (ION) demonstrated the highest differentiation ability for the presence of MASLD vs. Controls, with the area under the curve (AUC) being 0.894. For specific histological characterization of MASH, no NIT demonstrated adequate performance, while in the case of specific features of MASH, such as hepatocellular ballooning and lobular inflammation, ION demonstrated the best performance with AUC being close to or above 0.850. For fibrosis (F) classification, the highest AUC was reached by the aspartate aminotransferase to platelet ratio index (APRI) being ~0.850 yet only with the potential to differentiate the severe fibrosis stages (F3, F4) vs. mild or moderate fibrosis (F0-2) with an AUC > 0.900 in patients without T2DM. When we excluded patients with morbid obesity, the differentiation ability of APRI was improved, reaching AUC = 0.802 for differentiating the presence of fibrosis F2-4 vs. F0-1. The recommended by current guidelines index FIB-4 seemed to differentiate adequately between severe (i.e., F3-4) and mild or moderate fibrosis (F0-2) with an AUC = 0.820, yet this was not the case when FIB-4 was used to classify patients with fibrosis F2-4 vs. F0-1. Trying to improve the predictive value of all NITs, using Youden's methodology, to optimize the suggested cut-off points did not materially improve the results.The validation of currently available NITs using biopsy-proven samples provides new evidence for their ability to differentiate between specific disease stages, histological features, and, most importantly, fibrosis grading. The overall performance of the examined NITs needs to be further improved for applications in the clinic.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI5应助彼岸花开采纳,获得50
刚刚
仙乐完成签到,获得积分10
2秒前
笨笨的荧荧完成签到 ,获得积分10
4秒前
6秒前
醉熏的荣轩完成签到 ,获得积分10
9秒前
落羽发布了新的文献求助10
11秒前
豆子应助SASI采纳,获得20
11秒前
12秒前
喬老師完成签到,获得积分10
12秒前
落羽完成签到,获得积分10
17秒前
牛奶拌可乐完成签到 ,获得积分10
18秒前
漂亮采波发布了新的文献求助10
19秒前
joanna完成签到,获得积分10
22秒前
Vincent1990完成签到,获得积分10
23秒前
zcc111完成签到,获得积分10
26秒前
27秒前
贪玩的蝴蝶完成签到 ,获得积分10
30秒前
凌七发布了新的文献求助10
30秒前
Kevin完成签到,获得积分10
33秒前
wbs13521完成签到,获得积分0
35秒前
Ava应助宁紫涵采纳,获得10
36秒前
陈陈完成签到,获得积分10
38秒前
Jasper应助哈哈哈哈采纳,获得10
43秒前
45秒前
CHSLN完成签到 ,获得积分10
45秒前
谨慎秋珊完成签到 ,获得积分10
57秒前
Crrr完成签到,获得积分10
59秒前
1分钟前
1分钟前
明水发布了新的文献求助10
1分钟前
江洋大盗发布了新的文献求助10
1分钟前
哈哈哈哈发布了新的文献求助10
1分钟前
故意的睫毛膏完成签到 ,获得积分10
1分钟前
鲤鱼绮山完成签到 ,获得积分10
1分钟前
张西西完成签到 ,获得积分10
1分钟前
飞龙在天完成签到 ,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
Iron_five完成签到 ,获得积分10
1分钟前
wdd完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976600
求助须知:如何正确求助?哪些是违规求助? 3520674
关于积分的说明 11204470
捐赠科研通 3257316
什么是DOI,文献DOI怎么找? 1798683
邀请新用户注册赠送积分活动 877861
科研通“疑难数据库(出版商)”最低求助积分说明 806595