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Association between exposure to per- and perfluoroalkyl substances (PFAS) and reproductive hormones in human: A systematic review and meta-analysis

荟萃分析 置信区间 出版偏见 子群分析 医学 激素 睾酮(贴片) 梅德林 生理学 内分泌系统 内科学 性激素结合球蛋白 科学网 人口 人口学 环境卫生 生物 雄激素 生物化学 社会学
作者
Ling Li,Yingkun Guo,Shuai Ma,Hui Wen,Yupei Li,Jianhong Qiao
出处
期刊:Environmental Research [Elsevier BV]
卷期号:241: 117553-117553 被引量:19
标识
DOI:10.1016/j.envres.2023.117553
摘要

Per- and polyfluoroalkyl substances (PFAS) is persistent endocrine disrupting chemicals. Previous evidence suggests that exposure to PFAS is associated with reproductive hormone levels, but the results of relevant studies are inconsistent. The objective of our study is to determine the association between exposure to PFAS and reproductive hormone levels in gender-specific general population. Based on scientific search strategies, we systematically searched PubMed, Web of Science, Embase, Medline, and Scopus to obtain the eligible studies published before January 21, 2023. The quality of the included articles was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias tool. We combined the β coefficient and 95% confidence intervals (CI) using Stata.17 with random-effect model or fixed-effect model. We also performed subgroup analysis, sensitivity analysis, and Begger's and Egger's tests. Eleven studies involving 7714 participants were included. Meta-analysis showed that PFHxS exposure was positively associated with estradiol (E2) levels in female [β = 0.030, 95% CI: (0.013, 0.046), P = 0.000]. A negative association was found between PFOA [β = −0.012, 95% CI: (−0.023, −0.002), P = 0.017] and PFOS [β = −0.011; 95% CI: (−0.021, −0.000), P = 0.042] exposure with male testosterone (TT) levels. In the subgroup analysis, there were stronger associations in children than in adults. And the high heterogeneity was mainly due to the cross-sectional studies. Publication bias was not found in most of the analyses. Our study showed that PFAS exposure was significantly associated with reproductive hormone levels. Further related studies are needed to identify the association and potential mechanism in the future.
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