斑马鱼
后代
犬尿氨酸
生物
孵化
代谢物
胚胎发生
胎儿
犬尿氨酸途径
怀孕
胚胎
内分泌学
细胞生物学
生物化学
遗传学
色氨酸
氨基酸
基因
作者
Marta Marszałek‐Grabska,Kinga Gaweł,Nataliia Kosheva,Tomasz Kocki,Waldemar A. Turski
出处
期刊:Cells
[MDPI AG]
日期:2023-09-06
卷期号:12 (18): 2224-2224
被引量:2
标识
DOI:10.3390/cells12182224
摘要
Proper nutrition and supplementation during pregnancy and breastfeeding are crucial for the development of offspring. Kynurenine (KYN) is the central metabolite of the kynurenine pathway and a direct precursor of other metabolites that possess immunoprotective or neuroactive properties, with the ultimate effect on fetal neurodevelopment. To date, no studies have evaluated the effects of KYN on early embryonic development. Thus, the aim of our study was to determine the effect of incubation of larvae with KYN in different developmental periods on the behavior of 5-day-old zebrafish. Additionally, the effects exerted by KYN administered on embryonic days 1–7 (ED 1–7) on the behavior of adult offspring of rats were elucidated. Our study revealed that the incubation with KYN induced changes in zebrafish behavior, especially when zebrafish embryos or larvae were incubated with KYN from 1 to 72 h post-fertilization (hpf) and from 49 to 72 hpf. KYN administered early during pregnancy induced subtle differences in the neurobehavioral development of adult offspring. Further research is required to understand the mechanism of these changes. The larval zebrafish model can be useful for studying disturbances in early brain development processes and their late behavioral consequences. The zebrafish-medium system may be applicable in monitoring drug metabolism in zebrafish.
科研通智能强力驱动
Strongly Powered by AbleSci AI