富血小板血浆
骨关节炎
血小板裂解物
医学
沃马克
血小板
关节软骨
内科学
病理
替代医学
作者
Sare Hosseini,Mohammad Sadegh Soltani‐Zangbar,Majid Zamani,Yoda Yaghoubi,Reza Rikhtegar Ghiasi,Roza Motavalli,Ali Ghassabi,Rahim Iranzad,Amir Mehdizadeh,Seyed Kazem Shakouri,Alireza Pishgahi,Mehdi Yousefi
标识
DOI:10.1080/08977194.2023.2227273
摘要
Autologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured by ELISA. All patients showed significant improvements in pain and function following treatment of KOA with PL and PRP compared to baseline. Moreover, PL's concentration of growth factors was significantly higher than PRP. A significant increase was also observed in all of the aforementioned mediators in both PRP and PL products compared to control. These results can introduce PL as a promising and alternative option for KOA therapy in the future.
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