加药
药代动力学
抗生素
医学
人口
抗菌剂
抗生素耐药性
药理学
重症监护医学
微生物学
生物
环境卫生
作者
Perrin Ngougni Pokem,Dorian Vanneste,Stef Schouwenburg,Alan Abdulla,Matthias Gijsen,Evelyn Dhont,Dimitri Van der Linden,Isabel Spriet,Pieter De Cock,Birgit C. P. Koch,Françoise Van Bambeke,Gert-Jan Wijnant
标识
DOI:10.1080/17425255.2024.2385403
摘要
Introduction β-Lactams are the most widely used antibiotics in children. Their optimal dosing is essential to maximize their efficacy, while minimizing the risk for toxicity and the further emergence of antimicrobial resistance. However, most β-lactams were developed and licensed long before regulatory changes mandated pharmacokinetic studies in children. As a result, pediatric dosing practices are poorly harmonized and off-label use remains common today.
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