化学
吲唑
炎症性肠病
磷酸二酯酶
药理学
酶抑制剂
酶
生物化学
疾病
立体化学
内科学
医学
作者
Lei Zheng,Kun Chen,Yifan Xie,Jiaxi Huang,Chuang Xia,Yi Bao,Huichang Bi,Sheng Wang,Zhong‐Zhen Zhou
标识
DOI:10.1016/j.ejmech.2024.116710
摘要
Inflammatory bowel disease (IBD) is a chronic and progressive condition with a significant global burden. Currently, available treatments primarily provide symptomatic relief and retard disease progression, yet they do not offer a cure and are frequently associated with adverse effects. Therefore, the discovery of new targets and therapeutic drugs for IBD is crucial. Phosphodiesterase 4 (PDE4) inhibitors have emerged as promising candidates in the search for effective IBD treatments, although dose-dependent side effects hamper their clinical utility. In this study, building upon heterocyclic biaryl derivatives (TPA16), we designed and synthesized a series of N
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