Cardiometabolic index is associated with increased bone mineral density: a population-based cross-sectional study

医学 骨矿物 骨质疏松症 股骨颈 全国健康与营养检查调查 内科学 转子 体质指数 人口 线性回归 骨密度 内分泌学 环境卫生 数学 统计
作者
Xujin Wu,Xixin Jin,Wei Xu,Chang She,Liubing Li,Yongtao Mao
出处
期刊:Frontiers in Public Health [Frontiers Media]
卷期号:12 被引量:1
标识
DOI:10.3389/fpubh.2024.1403450
摘要

Background Osteoporosis is a multifactorial bone disease in which lipid metabolism plays an important role. Bone Mineral Density (BMD) measured by Dual-energy X-ray Absorptiometry (DXA) is a critical indicator for diagnosing osteoporosis. The cardiometabolic index (CMI) is a novel metric that combines two quantitative indicators of blood lipids—triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C). This study explores the association between CMI and BMD and seeks to elucidate the role of lipid metabolism in the context of bone health. Methods Based on the data of the National Health and Nutrition Examination Survey (NHANES) 2017–March 2020-pre-pandemic, weighted multiple linear regression and smooth curve fitting were used to study the relationship between CMI and femoral BMD. Stratified analyses were also conducted for age, gender, BMI, ethnicity, diabetes and hypertension status. And, the saturation threshold effect of CMI was further analyzed using a two-stage linear regression model. Result This study enrolled a total of 1,650 participants (48.7% males), with an average age of 63.0 ± 8.6 years. After adjusting for multiple confounding factors, CMI was positively correlated with total femur BMD, trochanter BMD, and intertrochanter BMD, while the correlation with femur neck BMD was not statistically significant. In the fully adjusted model, each unit increase in CMI was associated with a 0.026 (g/cm 2 ) increase in total femur BMD, a 0.022 (g/cm 2 ) increase in trochanter BMD, and a 0.034 (g/cm 2 ) increase in intertrochanter BMD. Subjects in the highest quartile of CMI had a 0.034 (g/cm 2 ) increase in total femur BMD, a 0.035 (g/cm 2 ) increase in trochanter BMD, and a 0.039 (g/cm 2 ) increase in intertrochanter BMD in the fully-adjusted model compared to those in the lowest quartile. In addition, saturation was observed between CMI and total femur BMD, trochanter BMD and intertrochanter BMD, with saturation thresholds of 1.073, 1.431 and 1.073, respectively. Conclusion CMI is strongly associated with BMD, indicating its potential relevance in bone metabolism. However, the role of CMI in the context of bone health, especially regarding osteoporosis risk, requires further investigation in large-scale prospective studies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
WN发布了新的文献求助10
刚刚
sssyq发布了新的文献求助10
刚刚
2秒前
WY发布了新的文献求助10
3秒前
4秒前
4秒前
成就山河发布了新的文献求助10
4秒前
5秒前
领导范儿应助sssyq采纳,获得10
6秒前
6秒前
落寞的书易完成签到 ,获得积分10
7秒前
大方弘文发布了新的文献求助10
7秒前
7秒前
8秒前
谦让玲发布了新的文献求助10
8秒前
奇奇淼发布了新的文献求助10
8秒前
Lucas应助小田心采纳,获得10
9秒前
顺利紫山发布了新的文献求助10
9秒前
青春完成签到 ,获得积分10
9秒前
叶叶完成签到,获得积分10
10秒前
深情安青应助靓丽的发箍采纳,获得10
12秒前
壳米应助谦让玲采纳,获得10
15秒前
19秒前
上官若男应助哈哈哈哈采纳,获得10
19秒前
孙燕应助zhao采纳,获得30
19秒前
雪山完成签到,获得积分10
19秒前
19秒前
21秒前
谦让玲完成签到,获得积分10
21秒前
无花果应助讨厌科研采纳,获得10
22秒前
24秒前
24秒前
NexusExplorer应助hanleiharry1采纳,获得10
24秒前
26秒前
27秒前
28秒前
Owen应助八九采纳,获得10
30秒前
哈哈哈哈发布了新的文献求助10
30秒前
CAOHOU应助张wx_100采纳,获得10
30秒前
30秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174