氧化应激
过氧化氢
抗氧化剂
生物相容性
化学
活性氧
氧化磷酸化
右旋糖酐
氧化铁纳米粒子
纳米颗粒
氧化还原
生物化学
生物物理学
氧化铁
材料科学
纳米技术
无机化学
有机化学
生物
作者
Somu Yadav,Stuti Bhagat,Rajesh Singh,Pawan Kumar Maurya
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2024-08-09
标识
DOI:10.1093/gerona/glae197
摘要
Abstract Erythrocytes undergo several changes during human aging and age-related diseases and, thus, have been studied as biomarkers of the aging process. The present study aimed to explore the antioxidant ability of metal and metal oxide nanoparticles (NPs) such as iron oxide (Fe3O4), gold (Au), and silver (Ag) to mitigate age-related oxidative stress in human erythrocytes. Metal and metal oxide NPs behave like antioxidative enzymes, directly influencing redox pathways and thus have better efficiency. Additionally, biopolymer coatings such as dextran enhance the biocompatibility of these NPs. Therefore, dextran-coated Fe3O4, Au, and Ag NPs were synthesized using wet chemical methods and were characterized. Their hemocompatibility and ability to protect erythrocytes from age-induced oxidative stress were investigated. The Fe3O4 and Au NPs were observed to protect erythrocytes from hydrogen peroxide and age-induced oxidative damage, including decreased antioxidant levels, reduced activity of antioxidative enzymes, and increased amounts of oxidative species. Pre-treatment with NPs preserved the morphology and membrane integrity of the erythrocyte. However, Ag NPs induced oxidative stress in erythrocytes similar to hydrogen peroxide. Therefore, dextran-coated Fe3O4 and Au nanoparticles have the potential to be employed as antioxidant therapies against age-related oxidative stress.
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