sEH activity is associated with mortality in patients with ARDS: a retrospective cohort study

Aim: We hypothesized plasma sEH activity correlates with mortality in acute respiratory distress syndrome (ARDS) patients. Methods: Adult patients diagnosed with ARDS enrolled between 2017 and 2019 were included in this study. Results: A total of 337 adult patients met our inclusion criteria. Among them, 107 patients died within 28 days. The plasma sEH activity was higher in nonsurvivors relative to survivors. And a receiver operating characteristic curve with the area under the curve of 0.81 (95% confidence interval: 0.74–0.89) for the prediction of 28-day mortality was obtained. Its sensitivity and specificity were 72.5% and 74.6%, respectively. Conclusion: Elevated plasma sEH activity is associated with higher 28-day mortality in adult patients with ARDS.