癌症免疫疗法
重编程
免疫疗法
癌症
卫星
芯(光纤)
纳米技术
癌症研究
材料科学
化学
医学
细胞
物理
内科学
生物化学
天文
复合材料
作者
Xia Zhang,Guocheng Li,Jiaqi Yin,Wei Pan,Yanhua Li,Na Li,Bo Tang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-07-15
标识
DOI:10.1021/acs.nanolett.4c02657
摘要
Tumor-associated macrophages (TAMs), as the most prevalent immune cells in the tumor microenvironment, play a pivotal role in promoting tumor development through various signaling pathways. Herein, we have engineered a Se@ZIF-8 core–satellite nanoassembly to reprogram TAMs, thereby enhancing immunotherapy outcomes. When the nanoassembly reaches the tumor tissue, selenium nanoparticles and Zn2+ are released in response to the acidic tumor microenvironment, resulting in a collaborative effort to promote the production of reactive oxygen species (ROS). The generated ROS, in turn, activate the nuclear factor κB (NF-κB) signaling pathway, driving the repolarization of TAMs from M2-type to M1-type, effectively eliminating cancer cells. Moreover, the nanoassembly can induce the immunogenic death of cancer cells through excess ROS to expose calreticulin and boost macrophage phagocytosis. The Se@ZIF-8 core–satellite nanoassembly provides a potential paradigm for cancer immunotherapy by reversing the immunosuppressive microenvironment.
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