重组DNA
阿尔法(金融)
人体皮肤
化学
生物化学
生物
医学
外科
遗传学
结构效度
基因
患者满意度
作者
Young Un Kim,HyunJoon Gi,Eun Taik Jeong,Sang‐Kook Han,Woo-Young Seo,Young Jun Kim,Sang Bae Lee,KyeongJin Kim
标识
DOI:10.5483/bmbrep.2024-0107
摘要
Collagen type III, a member of the fibrillar collagen group, is a major component of the extracellular matrix in various internal organs, the vascular systems, and skin.It is essential to maintain the structural integrity and functionality of these tissues, and plays a significant role in wound healing, often found alongside collagen type I. Despite being the second most abundant collagen in human tissues after type I, its biological functions on various skin properties have not been thoroughly studied.In this study, we have isolated and developed an effective recombinant protein derived from human collagen type III alpha 1 chain (hCOL3A1).Our findings demonstrate that the recombinant proteins hCOL3A1-THR-M1 and M4 stimulate cell proliferation and collagen biosynthesis in human dermal fibroblasts (HDFs), and enhance wound healing.Notably, hCOL3A1-THR-M1 (referred to as HUCOLLATIN3) specifically penetrates both the epidermal and dermal layers in a full-thickness skin model.These results collectively indicate that hCOL3A1-THR-M1 holds promise as a potential biomaterial to prevent skin aging.
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