Study on the Physicochemical and Release Properties of Surfactant Modified Bakla Starch

Our research described in this paper investigated the effect of Tween 20 as a nonionic surfactant on the physicochemical properties and drug release characteristics of Bakla starch. The effect of various concentrations of Tween 20 (0.5, 1 and 1.5% w/w) on various parameters of Bakla starch, including swelling behavior, solubility, moisture content, ash value, water holding capacity and the in-vitro drug release of paracetamol from its tablets, was examined. The incorporation of Tween 20 increased the swelling power, solubility, moisture content and water holding capacity, attributed to the alignment of its polar groups with the starch surface, which enhanced the hydrophilicity of the Bakla starch. The FTIR and XRD analysis suggested the formation of complexes of the starch with the Tween. A low concentration of Tween 20 enhanced the liquid penetration rate in tablets, whereas concentrations above 1% decreased it. This effect on penetration correlates with the enhanced release of paracetamol when Tween 20 is incorporated in the starch, underscoring the importance of the hydrophilic properties of a nonionic surfactant in controlling drug release. Therefore, our research focused on the impact of concentration and hydrophilicity of a nonionic surfactant and its interaction with Bakla starch on various physicochemical properties and the release rate of the paracetamol.