Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: the TANGO randomized controlled trial

内科学 医学 甘油三酯 脂肪肝 十五酸 代谢综合征 地中海饮食法 随机对照试验 内分泌学 脂肪酸 胆固醇 胃肠病学 生理学 生物 肥胖 疾病 生物化学
作者
Yu Chung Chooi,Qinze Arthur Zhang,Faidon Magkos,Maisie Ng,Navin Michael,Xiaorong Wu,Vera Sergeyevna Brok Volchanskaya,Xianning Lai,Elvy Riani Wanjaya,Untzizu Elejalde,Chew Chan Goh,Clara Poh Lian Yap,Long Hui Wong,Kevin Lim,S. Sendhil Velan,Jadegoud Yaligar,Mark Muthiah,Yap Seng Chong,Evelyn Xiu Ling Loo,Johan G. Eriksson,Kezlyn Li Ming Lim,Mabel Shu Fung Kouk,Evelyn Wai Mei Chong,Munirah Abd Gani,Lisha Li,Vicky Tay,Yeshe Kway,Mukkesh Kumar,Suresh Anand Sadananthan,Kaijie Khoo,Danyu Koh,Rebecca Lim,Chin Wei Kang,Kwang Li Sin,Jun Wei Lim
出处
期刊:The American Journal of Clinical Nutrition [Elsevier BV]
卷期号:119 (3): 788-799 被引量:16
标识
DOI:10.1016/j.ajcnut.2023.11.013
摘要

Weight loss is the most effective treatment for non-alcoholic fatty liver disease (NAFLD). There is evidence that Mediterranean diets rich in unsaturated fatty acids and fiber have beneficial effects on weight homeostasis and metabolic risk factors in individuals with NAFLD. Studies have also shown that higher circulating concentrations of pentadecanoic acid (C15:0) are associated with lower risk for NAFLD. To examine the effects of a Mediterranean-like, culturally contextualized Asian diet rich in fiber and unsaturated fatty acids, with or without C15:0 supplementation, in Chinese females with NAFLD. In a double-blinded, parallel-design, randomized controlled trial, 88 Chinese females with NAFLD were randomized to one of three groups for 12-weeks: diet with C15:0 supplementation (n=31), diet without C15:0 supplementation (n=28), or control (habitual diet and no C15:0 supplementation, n=29). At baseline and after the intervention, body fat percentage, intrahepatic lipid content, muscle and abdominal fat, liver enzymes, cardiometabolic risk factors and gut microbiome were assessed. In intention-to-treat analysis, weight reductions of 4.0±0.5 kg (5.3%), 3.4±0.5 kg (4.5%), and 1.5±0.5 kg (2.1%) were achieved in the diet-with-C15:0, diet-without-C15:0, and the control groups, respectively. The proton density fat fraction (PDFF) of the liver decreased by 33%, 30% and 10%, respectively. Both diet groups achieved significantly greater reductions in body weight, liver PDFF, total cholesterol, gamma-glutamyl transferase, and triglyceride concentrations compared to the control group. C15:0 supplementation reduced LDL-cholesterol further, and increased abundance of Bifidobacterium adolescentis. Fat mass, visceral adipose tissue, subcutaneous abdominal adipose tissue (deep and superficial), insulin, glycated hemoglobin and blood pressure decreased significantly in all groups, in parallel with weight loss. Mild weight loss induced by a Mediterranean-like diet adapted for Asians has multiple beneficial health effects in women with NAFLD. C15:0 supplementation lowers LDL-cholesterol and may cause beneficial shifts in gut microbiome. clinicaltrials.gov, NCT05259475
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
guangyu完成签到,获得积分10
1秒前
学术老6完成签到,获得积分10
2秒前
c123完成签到 ,获得积分10
4秒前
恐怖稽器人完成签到,获得积分10
4秒前
WXR完成签到,获得积分10
5秒前
科研小白完成签到,获得积分10
5秒前
6秒前
可爱丸子完成签到,获得积分10
6秒前
皮汤汤完成签到 ,获得积分10
7秒前
JXDYYZK完成签到,获得积分10
8秒前
SYLH应助lu采纳,获得10
8秒前
Servant2023完成签到,获得积分10
8秒前
鸽子的迷信完成签到,获得积分10
10秒前
nine2652完成签到 ,获得积分10
11秒前
烂漫的睫毛完成签到 ,获得积分10
13秒前
量子星尘发布了新的文献求助10
13秒前
陈老太完成签到 ,获得积分10
14秒前
宇宇宇c完成签到,获得积分10
15秒前
zxt完成签到,获得积分10
16秒前
大橙子发布了新的文献求助10
19秒前
聪明静柏完成签到 ,获得积分10
21秒前
kimiwanano完成签到,获得积分10
23秒前
lu完成签到,获得积分10
24秒前
Profeto应助齐嫒琳采纳,获得10
25秒前
26秒前
情怀应助科研通管家采纳,获得10
27秒前
从来都不会放弃zr完成签到,获得积分10
31秒前
1459完成签到,获得积分10
33秒前
行者+完成签到,获得积分10
33秒前
GongSyi完成签到 ,获得积分10
34秒前
Boris完成签到 ,获得积分10
36秒前
哭泣笑柳完成签到,获得积分10
36秒前
万能图书馆应助大橙子采纳,获得10
39秒前
大眼睛土豆完成签到,获得积分10
43秒前
一条虫gg完成签到,获得积分10
46秒前
47秒前
48秒前
51秒前
大橙子发布了新的文献求助10
51秒前
dzy发布了新的文献求助10
55秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022