Copper-Catalyzed Desymmetric Silylative-Cyclization of 1,6-Diynes for Synthesis of Spirocyclic Compounds

Spiro rings such as spiroxindoles and spiroindanones are core skeletons in many pharmaceutically active molecules and natural products. Herein, we developed a copper-catalyzed cascade silylation-cyclization reactions of 1,6-diynes which enabled...