医学
阻塞性睡眠呼吸暂停
气道
呼吸系统
睡眠呼吸暂停
睡眠(系统调用)
重症监护医学
心脏病学
麻醉
内科学
计算机科学
操作系统
作者
Samuel S. Epstein,Dale Jun,Jane C. Deng,Michelle Zeidler
标识
DOI:10.1016/j.jsmc.2024.02.002
摘要
Obstructive sleep apnea is a prevalent sleep disorder characterized by recurrent episodes of partial or complete upper airway collapse during sleep, leading to disrupted breathing patterns and intermittent hypoxia. OSA results in systemic inflammation but also directly affects the upper and lower airways leading to upregulation of inflammatory pathways and alterations of the local microbiome. These changes result in increased susceptibility to respiratory infections such as influenza, COVID-19, and bacterial pneumonia. This relationship is more complex and bidirectional in individuals with chronic lung disease such as chronic obstructive lung disease, interstitial lung disease and bronchiectasis.
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