自愈水凝胶
微血管
生物医学工程
再生(生物学)
血管
纤维化
生物相容性
新生血管
材料科学
免疫组织化学
病理
医学
血管生成
生物
细胞生物学
内科学
高分子化学
冶金
作者
Shih‐Yen Wei,Po‐Yu Chen,Min‐Chun Tsai,Ting‐Lun Hsu,Chia‐Chang Hsieh,Hsiu‐Wei Fan,Tzu‐Hsuan Chen,Ren‐Hao Xie,Guan‐Yu Chen,Ying‐Chieh Chen
标识
DOI:10.1002/adhm.202303320
摘要
Abstract Volumetric muscle loss (VML), a severe muscle tissue loss from trauma or surgery, results in scarring, limited regeneration, and significant fibrosis, leading to lasting reductions in muscle mass and function. A promising approach for VML recovery involves restoring vascular and neural networks at the injury site, a process not extensively studied yet. Collagen hydrogels have been investigated as scaffolds for blood vessel formation due to their biocompatibility, but reconstructing blood vessels and guiding innervation at the injury site is still difficult. In this study, collagen hydrogels with varied densities of vessel‐forming cells are implanted subcutaneously in mice, generating pre‐vascularized hydrogels with diverse vessel densities (0–145 numbers/mm 2 ) within a week. These hydrogels, after being transplanted into muscle injury sites, are assessed for muscle repair capabilities. Results showed that hydrogels with high microvessel densities, filling the wound area, effectively reconnected with host vasculature and neural networks, promoting neovascularization and muscle integration, and addressing about 63% of the VML.
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