已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Association of sex hormones with non‐alcoholic fatty liver disease: An observational and Mendelian randomization study

孟德尔随机化 性激素结合球蛋白 激素 脂肪肝 医学 内科学 睾酮(贴片) 疾病 内分泌学 生理学 生物 遗传学 基因 基因型 雄激素 遗传变异
作者
Chenghao Weng,Zilun Shao,Meng Xiao,Mingyu Song,Yuxuan Zhao,Aolin Li,Yuanjie Pang,Tao Huang,Canqing Yu,Jun Lv,Liming Li,Dianjianyi Sun
出处
期刊:Liver International [Wiley]
卷期号:44 (5): 1154-1166 被引量:1
标识
DOI:10.1111/liv.15866
摘要

Abstract Background and Aims Sex‐specific associations of sex hormone‐binding globulin (SHBG) and bioavailable testosterone (BAT) with NAFLD remain indeterminate. We aimed to explore observational and genetically determined relationships between each hormone and NAFLD. Methods We included 187 395 men and 170 193 women from the UK Biobank. Linear and nonlinear Cox regression models and Mendelian randomization (MR) analysis were used to test the associations. Results During 12.49 years of follow‐up, 2209 male and 1886 female NAFLD cases were documented. Elevated SHBG levels were linearly associated with a lower risk of NAFLD in women (HR (95% CI), .71 (.63, .79)), but not in men (a “U” shape, p non‐linear < .001). Higher BAT levels were associated with a lower NAFLD risk in men (HR (95% CI), .81 (.71, .93)) but a higher risk in women (HR (95% CI): 1.25 (1.15, 1.36)). Genetically determined SHBG and BAT levels were linearly associated with NAFLD risk in women (OR (95% CI): .57 (.38, .87) and 2.21 (1.41, 3.26) respectively); in men, an “L‐shaped” MR association between SHBG levels and NAFLD risk was found ( p non‐linear = .016). The bidirectional MR analysis further revealed the effect of NAFLD on SHBG and BAT levels in both sexes. Conclusions Consistently, linear associations of lower SHBG and higher BAT levels with increased NAFLD risk were both conventionally and genetically found in women, while in men, SHBG acts in a nonlinear manner. In addition, NAFLD may affect SHBG and BAT levels.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
3秒前
4秒前
大福完成签到,获得积分10
5秒前
5秒前
ljycasey发布了新的文献求助10
8秒前
碧蓝皮卡丘完成签到,获得积分10
10秒前
14秒前
ljycasey完成签到,获得积分10
15秒前
天天快乐应助候月采纳,获得30
17秒前
19秒前
21秒前
25秒前
南与晚霞发布了新的文献求助10
26秒前
29秒前
29秒前
30秒前
默默完成签到,获得积分10
32秒前
Y123发布了新的文献求助10
34秒前
南与晚霞完成签到,获得积分10
35秒前
Rita发布了新的文献求助10
35秒前
lili发布了新的文献求助10
37秒前
inRe完成签到,获得积分10
37秒前
淡然元彤应助粉色棉毛裤采纳,获得10
39秒前
39秒前
Stitch完成签到 ,获得积分10
40秒前
雷锋完成签到 ,获得积分10
44秒前
SS发布了新的文献求助10
45秒前
英姑应助rebee采纳,获得10
46秒前
英俊的铭应助默默采纳,获得10
53秒前
呵呵发布了新的文献求助20
54秒前
55秒前
nenoaowu应助SS采纳,获得30
55秒前
嗯哼应助科研通管家采纳,获得20
57秒前
英俊的铭应助科研通管家采纳,获得10
57秒前
57秒前
嗯哼应助科研通管家采纳,获得20
57秒前
杳鸢应助科研通管家采纳,获得10
58秒前
杳鸢应助科研通管家采纳,获得10
58秒前
张可完成签到 ,获得积分10
58秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
Semiconductor Process Reliability in Practice 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 600
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3234488
求助须知:如何正确求助?哪些是违规求助? 2880858
关于积分的说明 8217231
捐赠科研通 2548429
什么是DOI,文献DOI怎么找? 1377761
科研通“疑难数据库(出版商)”最低求助积分说明 647959
邀请新用户注册赠送积分活动 623314