毛发生长
头发周期
发病机制
头皮
内分泌学
体外
脱发
化学
细胞凋亡
内科学
细胞毒性
表型
癌症研究
毛囊
医学
皮肤病科
生物化学
生理学
基因
作者
Lijuan Zhou,Ruiming Hu,Yuan Sheng,Xuchao Wang,Shaohua Qi,Jun Zhao,Ying Miao,Ying Zhao,Feng Xu,Wenyu Wu,Zhong‐Fa Lu,Qinping Yang
摘要
Abstract The available interventions for androgenic alopecia (AGA), the most common type of hair loss worldwide, remain limited. The insulin growth factor (IGF) system may play an important role in the pathogenesis of AGA. However, the exact role of IGF binding protein‐related protein 1 (IGFBP‐rP1) in hair growth and AGA has not been reported. In this study, we first found periodic variation in IGFBP‐rP1 during the hair cycle transition in murine hair follicles (HFs). We further demonstrated that IGFBP‐rP1 levels were lower in the serum and scalp HFs of individuals with AGA than in those of healthy controls. Subsequently, we verified that IGFBP‐rP1 had no cytotoxicity to human outer root sheath cells (HORSCs) and that IGFBP‐rP1 reversed the inhibitory effects of DHT on the migration of HORSCs in vitro. Finally, a DHT‐induced AGA mouse model was created. The results revealed that the expression of IGFBP‐rP1 in murine HFs was downregulated after DHT treatment and that subcutaneous injection of IGFBP‐rP1 delayed catagen occurrence and prolonged the anagen phase of HFs in mice with DHT‐induced AGA. The present work shows that IGFBP‐rP1 is involved in hair cycle transition and exhibits great therapeutic potential for AGA.
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