Effects of motor cortical and peripheral axonal hyperexcitability on survival in amyotrophic lateral sclerosis

肌萎缩侧索硬化 磁刺激 神经科学 外围设备 沉默期 运动神经元 运动皮层 上运动神经元 医学 刺激 心理学 疾病 内科学 脊髓
作者
Ryo Otani,Kazumoto Shibuya,Yoichi Suzuki,Tomoki Suichi,Marie Morooka,Yuya Aotsuka,Moeko Ogushi,Satoshi Kuwabara
出处
期刊:Journal of Neurology, Neurosurgery, and Psychiatry [BMJ]
卷期号:95 (8): 730-736 被引量:3
标识
DOI:10.1136/jnnp-2023-333039
摘要

Background Increased ‘cortical’ and ‘peripheral’ excitability are reportedly associated with shorter survival in amyotrophic lateral sclerosis (ALS) patients, suggesting that hyperexcitability contributes to motor neuron death. However, whether upper or lower motor function has a greater impact on survival is unclear. We aimed to investigate the component that strongly impacts the prognosis of ALS. Methods A total of 103 consecutive patients with ALS who underwent cortical (threshold tracking transcranial magnetic stimulation (TMS)) and motor nerve excitability tests were included. Motor cortical excitability was evaluated using short-interval intracortical inhibition (SICI) during TMS. Motor axonal excitability was assessed using the strength-duration time constant (SDTC). Survival time was defined as the time from examination to death or tracheostomy. Results Compared with healthy subjects, patients with ALS had lower SICI and longer SDTC (p<0.05), indicating increased excitability of cortical motor neurons and motor axons. According to the SICI and SDTC findings, patients were divided into the following four groups: ‘cortical high and peripheral high (high-high)’, ‘high-low’, ‘low-high’ and ‘low-low’ groups. In Kaplan-Meier curves, the ‘high-high’ and ‘low-high’ groups showed significantly shorter survival than the other groups. Multivariate analysis revealed that increased cortical (HR=5.3, p<0.05) and peripheral (HR=20.0, p<0.001) excitability were significantly associated with shorter survival. Conclusions In patients with ALS, both motor cortical and peripheral hyperexcitability independently affected survival time, with peripheral hyperexcitability having a greater impact on shorter survival. The modulation of neuronal/axonal excitability is a potential therapeutic target for ALS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
sherry完成签到 ,获得积分10
刚刚
情怀应助鱼咬羊采纳,获得10
刚刚
孙Tuan完成签到,获得积分10
刚刚
海东来应助哈哈哈哈采纳,获得150
刚刚
科研通AI2S应助许初采纳,获得10
1秒前
1秒前
芒果完成签到 ,获得积分10
2秒前
豆豆发布了新的文献求助10
2秒前
2秒前
lovexy完成签到,获得积分10
2秒前
八一完成签到,获得积分10
2秒前
糊涂的保温杯完成签到,获得积分10
3秒前
薛吒发布了新的文献求助10
4秒前
明尘完成签到,获得积分10
4秒前
5秒前
zwk发布了新的文献求助10
5秒前
Rondab应助李龙章采纳,获得10
5秒前
大个应助樱桃汽水怪兽采纳,获得10
7秒前
7秒前
7秒前
完美世界应助vicky采纳,获得30
7秒前
林月完成签到,获得积分10
7秒前
8秒前
PYF应助故意的鸿涛采纳,获得10
8秒前
123123完成签到,获得积分10
9秒前
Lucifer发布了新的文献求助10
10秒前
10秒前
12秒前
ZZY发布了新的文献求助10
12秒前
raincloud完成签到,获得积分10
12秒前
13秒前
内向寒云发布了新的文献求助10
14秒前
nanjiren发布了新的文献求助10
14秒前
14秒前
英俊的铭应助ee采纳,获得10
15秒前
15秒前
丰D完成签到,获得积分10
15秒前
充电宝应助无梦为安采纳,获得10
15秒前
赘婿应助知性的紫寒采纳,获得10
16秒前
16秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974797
求助须知:如何正确求助?哪些是违规求助? 3519250
关于积分的说明 11197623
捐赠科研通 3255405
什么是DOI,文献DOI怎么找? 1797769
邀请新用户注册赠送积分活动 877156
科研通“疑难数据库(出版商)”最低求助积分说明 806202