成纤维细胞
生物
细胞生物学
背景(考古学)
细胞外基质
免疫系统
伤口愈合
炎症
免疫学
细胞培养
遗传学
古生物学
作者
Matthew B. Buechler,Yung-Gun Chung,Matthew B. Buechler
出处
期刊:F1000Research
[F1000 Research Ltd]
日期:2024-02-20
卷期号:13: 126-126
标识
DOI:10.12688/f1000research.143511.1
摘要
Fibroblasts are mesenchymal cells that are responsible for creating and maintaining tissue architecture through the production of extracellular matrix. These cells also play critical roles in processes such as wound repair and immune modulation in normal tissues and various disease states including fibrosis, autoimmunity, and cancer. Fibroblasts have a complex repertoire of functions that vary by organ, inflammatory state, and the developmental stage of an organism. How fibroblasts manage so many functions in such a context-dependent manner represents a gap in our understanding of these cells. One possibility is that a tissue-resident precursor cell state exists that provides the fibroblast lineage with flexibility during growth, inflammation, or other contexts that require dynamic tissue changes. Recent work has suggested that a precursor fibroblast cell state is marked by expression of Peptidase inhibitor 16 (Pi16). This review aims to concatenate and compare studies on fibroblasts that express Pi16 to clarify the roles of this cell state in fibroblast lineage development and other functions.
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