病毒性脑炎
药品
抗病毒药物
细胞外
脑炎
病毒学
翻译(生物学)
计算生物学
神经科学
生物
细胞生物学
病毒
药理学
生物化学
基因
信使核糖核酸
作者
Lei Wang,Huajie Chen,Zhigang Wang,Di Ning,Wei Zhao,Virgile Rat,Don C. Lamb,Dai‐Wen Pang,Shu‐Lin Liu
标识
DOI:10.1002/adma.202311457
摘要
Abstract The extracellular space (ECS) is an important barrier against viral attack on brain cells, and dynamic changes in ECS microstructure characteristics are closely related to the progression of viral encephalitis in the brain and the efficacy of antiviral drugs. However, mapping the precise morphological and rheological features of the ECS in viral encephalitis is still challenging so far. Here, we developed a robust approach using single‐particle diffusional fingerprinting (SPDF) of quantum dots combined with machine learning to map ECS features in the brain and predict the efficacy of antiviral encephalitis drugs. Our results demonstrated that this approach can characterize the microrheology and geometry of the brain ECS at different stages of viral infection and identify subtle changes induced by different drug treatments. This approach provides a potential platform for drug proficiency assessment and is expected to offer a reliable basis for clinical translation of drugs. This article is protected by copyright. All rights reserved
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