医学
免疫学
1型糖尿病
糖尿病
系统性狼疮
2型糖尿病
白细胞介素
内科学
细胞因子
疾病
内分泌学
作者
Wei-Zi Qin,Xu‐Fan Wang,Rui Leng,Wenjing Xu,Feifei Wang,Wei Zhao,Rui‐Xue Leng
出处
期刊:Lupus
[SAGE]
日期:2024-02-26
卷期号:33 (4): 403-408
标识
DOI:10.1177/09612033241235868
摘要
Objective Interleukin-18 (IL-18) is a proinflammatory cytokine. This study aims to determine whether there is a causal relationship between circulating IL-18 concentrations and the risk of inflammatory and autoimmune diseases. Methods We collected significant single nucleotide polymorphisms (SNPs) associated with circulating IL-18 levels ( p < 5 × 10 −8 ) as instrumental variables (IVs) from a genome-wide association study (GWAS) involving 21,758 individuals of European descent. We mainly employed the inverse-variance weighed (IVW) method of two-sample Mendelian randomization (TSMR) analysis to estimate the causality of circulating IL-18 levels on inflammatory and autoimmune diseases. Results The IVW method results showed evidence of a causal relationship between IL-18 and the risk of systemic lupus erythematosus (SLE) (OR = 1.32; 95% CI 1.15, 1.50; p < .001) and type 1 diabetes (T1D) (OR = 1.22; 95% CI 1.06, 1.42; p = .007) in individuals of European ancestry. No significant heterogeneity or horizontal pleiotropy for SLE and T1D was detected. The sensitivity analysis, which involved removing confounding SNP, produced similar results for SLE and T1D. The results of sensitivity analysis using leave-one-out method indicated no single SNP significantly influenced the analysis results. However, we did not find any significant findings for multiple sclerosis, psoriasis, asthma, and osteoarthritis. Conclusions Our analyses suggest that circulating IL-18 is significantly related to SLE and T1D and may serve as a potential target for the treatment of these diseases.
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