肌动蛋白
细胞生物学
蛋白酶
生物
翻译(生物学)
细胞质
MDia1公司
蛋氨酸
骨骼肌
肌动蛋白重塑
细胞骨架
肌动蛋白结合蛋白
肌动蛋白细胞骨架
蛋白质生物合成
生物化学
酶
信使核糖核酸
解剖
基因
氨基酸
细胞
作者
Peter Haahr,R. Galli,Lisa G. van den Hengel,Onno B. Bleijerveld,Justina Kazokaitė-Adomaitienė,Ji‐Ying Song,Lona J. Kroese,Paul Krimpenfort,Marijke P Baltissen,Michiel Vermeulen,Coen A.C. Ottenheijm,Thijn R. Brummelkamp
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-30
卷期号:377 (6614): 1533-1537
被引量:4
标识
DOI:10.1126/science.abq5082
摘要
Protein synthesis generally starts with a methionine that is removed during translation. However, cytoplasmic actin defies this rule because its synthesis involves noncanonical excision of the acetylated methionine by an unidentified enzyme after translation. Here, we identified C19orf54, named ACTMAP (actin maturation protease), as this enzyme. Its ablation resulted in viable mice in which the cytoskeleton was composed of immature actin molecules across all tissues. However, in skeletal muscle, the lengths of sarcomeric actin filaments were shorter, muscle function was decreased, and centralized nuclei, a common hallmark of myopathies, progressively accumulated. Thus, ACTMAP encodes the missing factor required for the synthesis of mature actin and regulates specific actin-dependent traits in vivo.
科研通智能强力驱动
Strongly Powered by AbleSci AI