Monitoring gait at home with radio waves in Parkinson’s disease: A marker of severity, progression, and medication response

步态 医学 物理医学与康复 评定量表 帕金森病 疾病 物理疗法 最佳步行速度 运动障碍 临床试验 内科学 心理学 发展心理学
作者
Yingcheng Liu,Guo Zhang,Christopher G. Tarolli,Rumen Hristov,Stella Jensen-Roberts,Emma Waddell,Taylor Myers,Meghan Pawlik,Julia Soto,Renée Wilson,Yuzhe Yang,Timothy Nordahl,Karlo J. Lizárraga,Jamie Adams,Ruth B. Schneider,Karl Kieburtz,Terry D. Ellis,E. Ray Dorsey,Dina Katabi
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science]
卷期号:14 (663) 被引量:57
标识
DOI:10.1126/scitranslmed.adc9669
摘要

Parkinson’s disease (PD) is the fastest-growing neurological disease in the world. A key challenge in PD is tracking disease severity, progression, and medication response. Existing methods are semisubjective and require visiting the clinic. In this work, we demonstrate an effective approach for assessing PD severity, progression, and medication response at home, in an objective manner. We used a radio device located in the background of the home. The device detected and analyzed the radio waves that bounce off people’s bodies and inferred their movements and gait speed. We continuously monitored 50 participants, with and without PD, in their homes for up to 1 year. We collected over 200,000 gait speed measurements. Cross-sectional analysis of the data shows that at-home gait speed strongly correlates with gold-standard PD assessments, as evaluated by the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III subscore and total score. At-home gait speed also provides a more sensitive marker for tracking disease progression over time than the widely used MDS-UPDRS. Further, the monitored gait speed was able to capture symptom fluctuations in response to medications and their impact on patients’ daily functioning. Our study shows the feasibility of continuous, objective, sensitive, and passive assessment of PD at home and hence has the potential of improving clinical care and drug clinical trials.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
煎锅完成签到,获得积分10
刚刚
大大大大黄完成签到,获得积分10
1秒前
郭mm发布了新的文献求助10
1秒前
一一完成签到,获得积分10
1秒前
甜美白昼发布了新的文献求助10
2秒前
tangchao完成签到,获得积分10
2秒前
小路完成签到,获得积分10
2秒前
善良紫完成签到,获得积分10
3秒前
Rae完成签到,获得积分10
3秒前
星辰大海应助荆棘鸟采纳,获得10
3秒前
4秒前
LLLLL发布了新的文献求助10
4秒前
Lc完成签到,获得积分10
4秒前
qawsed完成签到,获得积分10
5秒前
5秒前
一蓑烟雨任平生完成签到,获得积分0
5秒前
朴素难敌完成签到,获得积分10
5秒前
专注的树完成签到,获得积分10
6秒前
拽根大恐龙完成签到,获得积分10
6秒前
soory完成签到,获得积分10
7秒前
7秒前
自信的完成签到,获得积分10
7秒前
Haley完成签到,获得积分10
7秒前
快去学习吧完成签到,获得积分20
7秒前
CHF发布了新的文献求助10
8秒前
凶狠的食铁兽完成签到,获得积分10
8秒前
微笑鹤完成签到,获得积分10
9秒前
jyy应助无语采纳,获得10
10秒前
10秒前
DCC完成签到,获得积分10
10秒前
一进实验室就犯困完成签到,获得积分10
11秒前
LLLLL完成签到,获得积分10
11秒前
柔弱的问梅完成签到,获得积分10
11秒前
ZAP完成签到,获得积分10
12秒前
123完成签到,获得积分10
12秒前
云墨完成签到,获得积分10
12秒前
羊青丝完成签到,获得积分10
12秒前
lilian完成签到,获得积分10
12秒前
郭mm发布了新的文献求助10
13秒前
温婉完成签到,获得积分10
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968603
求助须知:如何正确求助?哪些是违规求助? 3513420
关于积分的说明 11168029
捐赠科研通 3248900
什么是DOI,文献DOI怎么找? 1794540
邀请新用户注册赠送积分活动 875187
科研通“疑难数据库(出版商)”最低求助积分说明 804676