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Monitoring gait at home with radio waves in Parkinson’s disease: A marker of severity, progression, and medication response

步态 医学 物理医学与康复 评定量表 帕金森病 疾病 物理疗法 最佳步行速度 运动障碍 临床试验 内科学 心理学 发展心理学
作者
Yingcheng Liu,Guo Zhang,Christopher G. Tarolli,Rumen Hristov,Stella Jensen-Roberts,Emma Waddell,Taylor Myers,Meghan Pawlik,Julia Soto,Renée Wilson,Yuzhe Yang,Timothy Nordahl,Karlo J. Lizárraga,Jamie Adams,Ruth B. Schneider,Karl Kieburtz,Terry D. Ellis,E. Ray Dorsey,Dina Katabi
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science]
卷期号:14 (663) 被引量:57
标识
DOI:10.1126/scitranslmed.adc9669
摘要

Parkinson’s disease (PD) is the fastest-growing neurological disease in the world. A key challenge in PD is tracking disease severity, progression, and medication response. Existing methods are semisubjective and require visiting the clinic. In this work, we demonstrate an effective approach for assessing PD severity, progression, and medication response at home, in an objective manner. We used a radio device located in the background of the home. The device detected and analyzed the radio waves that bounce off people’s bodies and inferred their movements and gait speed. We continuously monitored 50 participants, with and without PD, in their homes for up to 1 year. We collected over 200,000 gait speed measurements. Cross-sectional analysis of the data shows that at-home gait speed strongly correlates with gold-standard PD assessments, as evaluated by the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III subscore and total score. At-home gait speed also provides a more sensitive marker for tracking disease progression over time than the widely used MDS-UPDRS. Further, the monitored gait speed was able to capture symptom fluctuations in response to medications and their impact on patients’ daily functioning. Our study shows the feasibility of continuous, objective, sensitive, and passive assessment of PD at home and hence has the potential of improving clinical care and drug clinical trials.
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