细胞内
化学
分泌物
细胞生物学
细胞质
生物物理学
体内
脂质体
体外
生物化学
生物
生物技术
作者
Hongsen Tian,Chenhui Gu,Wenshuai Li,Tong Tong,Yunsheng Wang,Yang Yang,Haoli Wang,Zhanqiu Dai,Pengfei Chen,Feng Wang,Xianfeng Lin,Liqing Shangguan,Linfeng Wang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-05-15
卷期号:23 (10): 4101-4110
被引量:4
标识
DOI:10.1021/acs.nanolett.2c04295
摘要
Osteoporosis is a global disease caused by abnormal overactivation of osteoclasts. The acidic environment in sealing zone of osteoclasts with H+ pumped from cytoplasm is critical to the maturation of osteoclasts. Therefore, reducing the intracellular H+ concentration can reduce the H+ secretion of osteoclasts from the source. In our study, we developed a novel nanovesicle which encapsulates Na2HPO4 with a liposome hybridizes with preosteoclast membrane (Na2HPO4@Lipo-pOCm). These nanovesicles release Na2HPO4 into the preosteoclast by targeting preosteoclasts and membrane fusion, reducing the intracellular H+ concentration, and achieve biological cascade regulation of osteoclasts through simple pH regulation. In vitro and in vivo experiments confirmed that these nanovesicles reduce mitochondrial membrane potential by decreasing intracellular H+ concentration, thereby reducing the ROS in osteoclasts as well as the expression of the upstream transcription factor FOXM1 of Acp5. In short, this nanovesicle can significantly inhibit the osteoclasts and ameliorate osteoporosis caused by OVX.
科研通智能强力驱动
Strongly Powered by AbleSci AI