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Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development

医学 银屑病 银屑病性关节炎 内科学 队列 逻辑回归 多元分析 关节炎 胃肠病学 皮肤病科
作者
Alberto Floris,Cristina Mugheddu,Leonardo Sichi,Jasmine Anedda,Alessia Frau,Jessica Sorgia,Laura Li Volsi,Maria Teresa Paladino,Mattia Congia,Elisabetta Chessa,Maria Maddalena Angioni,Micaela Rita Naitza,Caterina Ferreli,Matteo Piga,Laura Atzori,Alberto Cauli
出处
期刊:Rheumatology [Oxford University Press]
被引量:2
标识
DOI:10.1093/rheumatology/keae257
摘要

Abstract Objective To assess the potential role of biologic treatment for psoriasis (PsO) in reducing the likelihood of psoriatic arthritis (PsA) development, through a detailed analysis that considered the different historical phases in PsA management, the different biologic classes and the different patterns of articular involvement. Methods A monocentric cohort of 1023 PsO patients underwent a rheumatological assessment in which clinical and therapeutic data were recorded. A chi-squared test and multivariate logistic regression analysis (adjusted for the main PsA risk factors) were performed to compare the likelihood of PsA development in different treatment groups. Results The PsA prevalence in PsO patients treated at least once with biologics was significantly lower than in patients never treated with biologics (8.9% vs 26.1%, P < 0.001). In multivariate analysis, a significantly (P < 0.01) lower likelihood of PsA development in biologic-treated patients was confirmed in the whole cohort (adjusted odds ratio [adjOR] 0.228), as well as in the subgroups of patients with PsO onset after 2005 (adjOR 0.264) and after 2014 (adjOR 0.179). Separately analysing the different biologic classes, the TNF (adjOR 0.206), IL-17 (adjOR 0.051) and IL-23 or 12/23 (adjOR 0.167) inhibitors were significantly (P < 0.01) associated with a lower likelihood of PsA development. Finally, patients treated with biologics had a significantly (P < 0.04) lower prevalence of both pure peripheral PsA (adjOR 0.182) and peripheral PsA with axial involvement (adjOR 0.115). Conclusions This study provides meaningful and concordant evidence supporting the significant role of different classes of biologics in reducing the likelihood of peripheral and axial PsA development.
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