孟德尔随机化
因果推理
医学
随机化
脑积水
心理学
内科学
生物信息学
生物
随机对照试验
遗传学
病理
精神科
基因
遗传变异
基因型
作者
Jianglong Lu,Xianpeng Wang,Fanjie Xu,Changjun Rao,Yuhang Guo,Zhipeng Su,Siyan Chen,Qun Li
标识
DOI:10.3389/fnagi.2024.1412434
摘要
Neuroinflammatory processes have been identified as playing a crucial role in the pathophysiology of various neurodegenerative diseases, including idiopathic normal-pressure hydrocephalus (iNPH). iNPH, defined as a common disease of cognitive impairment in older adults, poses major challenges for therapeutic interventions owing to the stringent methodological requirements of relevant studies, clinical heterogeneity, unclear etiology, and uncertain diagnostic criteria. This study aims to assess the relationship between circulating inflammatory biomarkers and iNPH risk using bidirectional two-sample Mendelian randomization (MR) combined with meta-analysis.
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