葡萄糖稳态
平衡
内分泌学
内科学
睡眠(系统调用)
医学
糖尿病
胰岛素抵抗
计算机科学
操作系统
作者
Natália Stinghen Tonet,Danilo Francisco da Silva Marçal,Flávia Natividade da Silva,Henver S. Brunetta,Marcelo A. Mori,Gustavo Jorge dos Santos,Eduardo Luiz Gasnhar Moreira,Alex Rafacho
出处
期刊:Sleep
[Oxford University Press]
日期:2024-05-24
卷期号:47 (7)
标识
DOI:10.1093/sleep/zsae118
摘要
Abstract Study Objectives Sleep deprivation is a potential risk factor for metabolic diseases, including obesity and type 2 diabetes. We evaluated the impacts of moderate chronic sleep deprivation on glucose and lipid homeostasis in adult rats. Methods Wistar rats (both sexes) were sleep-perturbed daily for 2 hours at the early (06:00–08:00) and the late light cycle (16:00–18:00) five days a week (except weekends) for 4 weeks. Results Sleep perturbation (SP) resulted in reduced body weight gain in both sexes, associated with altered food intake and reduced adiposity. SP did not alter the short- or long-term memories or cause anxiogenic behavior. No major changes were observed in the plasma insulin, leptin, triacylglycerol, non-esterified fatty acids, and blood glucose upon SP. After SP, females exhibited a transitory glucose intolerance, while males became glucose intolerant at the end of the experimental period. Male rats also developed higher insulin sensitivity at the end of the SP protocol. Morphometric analyses revealed no changes in hepatic glycogen deposition, pancreatic islet mass, islet-cell distribution, or adrenal cortex thickness in SP rats from both sexes, except for lower adipocyte size compared with controls. We did not find homogeneous changes in the relative expression of circadian and metabolic genes in muscle or hepatic tissues from the SP rats. Conclusions Moderate chronic SP reduces visceral adiposity and causes glucose intolerance with a more pronounced impact on male rats, reinforcing the metabolic risks of exposure to sleep disturbances.
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