CIC–NUTM1 sarcoma in an 8‐year‐old female patient with a new fusion: A case report

Pediatric Blood & CancerEarly View e30348 LETTER TO THE EDITOR CIC–NUTM1 sarcoma in an 8-year-old female patient with a new fusion: A case report Yangyang Ma, Corresponding Author Yangyang Ma [email protected] orcid.org/0000-0002-3617-9941 Department of Pathology, Children's Hospital of Fudan University, Shanghai, China Correspondence Yangyang Ma, Department of Pathology, Children's Hospital of Fudan University, Shanghai, China. Email: [email protected]Search for more papers by this authorJiayan Feng, Jiayan Feng Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this authorDi Ding, Di Ding Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this authorFeng Tian, Feng Tian Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this authorJing Zhao, Jing Zhao Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this author Yangyang Ma, Corresponding Author Yangyang Ma [email protected] orcid.org/0000-0002-3617-9941 Department of Pathology, Children's Hospital of Fudan University, Shanghai, China Correspondence Yangyang Ma, Department of Pathology, Children's Hospital of Fudan University, Shanghai, China. Email: [email protected]Search for more papers by this authorJiayan Feng, Jiayan Feng Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this authorDi Ding, Di Ding Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this authorFeng Tian, Feng Tian Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this authorJing Zhao, Jing Zhao Department of Pathology, Children's Hospital of Fudan University, Shanghai, ChinaSearch for more papers by this author First published: 02 May 2023 https://doi.org/10.1002/pbc.30348Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES 1 WHO Classification of Tumours Soft Tissue and Bone Tumours. 5th ed. International Agency for Research on Cancer; 2020: 330- 332. 2Richkind KE, Romansky SG, Finklestein JZ. t(4;19)(q35;q13.1): a recurrent change in primitive mesenchymal tumors? Cancer Genet Cytogenet. 1996; 87: 71- 74. 3Kawamura-Saito M, Yamazaki Y, Kaneko K, et al. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet. 2006; 15: 2125- 2137. 4Watson S, Perrin V, Guillemot D, et al. Transcriptomic definition of molecular subgroups of small round cell sarcomas. J Pathol. 2018; 245: 29- 40. 5Sugita S, Arai Y, Aoyama T, et al. NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma. Hum Pathol. 2017; 65: 225- 230. 6Song K, Huang Y, Xia CD, et al. A case of CIC-rearranged sarcoma with CIC-LEUTX gene fusion in spinal cord. Neuropathology. 2022; 42: 555- 562. 7Mangray S, Kelly DR, LeGuellec S, et al. Clinicopathologic features of a series of primary renal CIC-rearranged sarcomas with comprehensive molecular analysis. Am J Surg Pathol. 2018; 42: 1360- 1369. 8Schaefer IM, Dal Cin P, Landry LM, et al. CIC–NUTM1 fusion: a case which expands the spectrum of NUT-rearranged epithelioid malignancies. Genes Chromosomes Cancer. 2018; 57: 446- 451. 9Biederman LE, Lee K, Yeager ND, et al. CIC::NUTM1 sarcoma mimicking primitive myxoid mesenchymal tumour of infancy: report of a case. Histopathology. 2022; 81: 131- 133. 10Le Loarer F, Pissaloux D, Watson S, et al. Clinicopathologic features of CIC–NUTM1 sarcomas, a new molecular variant of the family of CIC-fused sarcomas. Am J Surg Pathol. 2019; 43: 268- 276. 11Yang S, Liu L, Yan Y, et al. CIC–NUTM1 sarcomas affecting the spine. Arch Pathol Lab Med. 2022; 146: 735- 741. 12Carrabotta M, Laginestra MA, Durante G, et al. Integrated molecular characterization of patient-derived models reveals therapeutic strategies for treating CIC-DUX4 sarcoma. Cancer Res. 2022; 82: 708- 720. 13Bosnakovski D, Ener ET, Cooper MS, et al. Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma. Oncogenesis. 2021; 10: 68. Early ViewOnline Version of Record before inclusion in an issuee30348 ReferencesRelatedInformation