Sun Exposure and its Impact on Keratinocyte Senescence and Function

Aging is characterized by a time-dependent decline of cellular and organismal function. The skin is the largest organ of the body and protects it against environmental insults such as UVR and pollution, various stresses including microbes and mechanical forces, and also plays a role in thermoregulation. In the skin, the aging process commonly manifests as observable phenotypes, such as wrinkling, thinning, loss of elasticity, and aberrant pigmentation (Fitsiou et al., 2021; Wang and Dreesen, 2018).