琥珀酰亚胺
级联
双环分子
丁二酰亚胺
组合化学
化学
级联反应
内酯
立体化学
有机化学
催化作用
色谱法
作者
Yimei Song,Chaofei Wu,Jinhai Zhang,Wen‐Hai Zhang,Xin Qin,Yixiao Yang,Guowei Kang,Jun Jiang,Hongxin Liu
摘要
Herein, a novel switchable multipath cascade cyclization via chemodivergent reaction between readily available ketoamides and deconjugated butenolides was developed to efficiently synthesize γ-lactone fused γ-lactams and succinimide fused hemiketals. The Aldol/aza-Michael reaction and Aldol/imidation/hemiketalization reaction were enabled by catalytic amounts of two bases, namely tetramethyl guanidine and NaOAc. A wide range of substrate scope with diverse functional group compatibility was demonstrated to deliver the corresponding products with good yield and excellent diastereoselectivity (>60 examples).
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