室下区
生物
少突胶质细胞
神经科学
祖细胞
聚唾液酸
人口
神经干细胞
细胞生物学
髓鞘
神经细胞粘附分子
室管膜细胞
干细胞
中枢神经系统
细胞
医学
细胞粘附
遗传学
环境卫生
作者
Brahim Nait‐Oumesmar,Laurence Decker,François Lachapelle,Virginia Avellana‐Adalid,Corinne Bachelin,Anne Baron‐Van Evercooren
标识
DOI:10.1046/j.1460-9568.1999.00873.x
摘要
Abstract Identifying a source of cells with the capacity to generate oligodendrocytes in the adult CNS would help in the development of strategies to promote remyelination. In the present study, we examined the ability of the precursor cells of the adult mouse subventricular zone (SVZ) to differentiate into remyelinating oligodendrocytes. After lysolecithin‐induced demyelination of the corpus callosum, progenitors of the rostral SVZ (SVZa) and the rostral migratory pathway (RMS), expressing the embryonic polysialylated form of the neural cell adhesion molecule (PSA‐NCAM), increased progressively with a maximal expansion occurring after 2 weeks. This observation correlated with an increase in the proliferation activity of the neural progenitors located in the SVZa and RMS. Moreover, polysialic acid (PSA)‐NCAM‐immunoreactive cells arizing from the SVZa were detected in the lesioned corpus callosum and within the lesion. Tracing of the constitutively cycling cells of the adult SVZ and RMS with 3 H‐thymidine labelling showed their migration toward the lesion and their differentiation into oligodendrocytes and astrocytes but not neurons. These data indicate that, in addition to the resident population of quiescent oligodendrocyte progenitors of the adult CNS, neural precursors from the adult SVZ constitute a source of oligodendrocytes for myelin repair.
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