粘液
生物利用度
体内
肿胀 的
最大值
化学
结晶度
控制释放
药物输送
微球
药理学
粒径
赋形剂
色谱法
材料科学
化学工程
医学
生物技术
有机化学
植物
工程类
物理化学
复合材料
生物
结晶学
作者
Shazia Akram Ghumman,Sajid Bashir,Sobia Noreen,Abdul Muqeet Khan,Muhammad Zubair Malik
标识
DOI:10.1016/j.ijbiomac.2019.08.100
摘要
Taro corms mucilage (TCM)-alginate microspheres had been prepared using TCM and alginate as blend and coated form in various ratios through inotropic gelation approach. The prepared microspheres have been of sphere-formed having coarse surface with average particle size within the range 498 μm ± 0.17 to 715 μm ± 0.34. The drug entrapment efficiency was 74.33 ± 0.04% to 89.63 ± 0.01% and swelling of microspheres followed the pattern (blended >coated >plain). FTIR research showed that there had been no interactions among pregabalin and polymers used; these microspheres were further characterized by DSC and XRD. The in vitro drug release followed sustained release (Korsmeyer-Peppas model) pattern (R2 = 0.9552–0.9906) and value of n > 1 showed that drug released by means of anomalous (non-Fickian) diffusion. The in vivo research established that there were highly significant difference with p < 0.001 within the pharmacokinetic parameters (Cmax, t½, AUC0-∞, Ke), while pregabalin microspheres in comparison to pure drug. Therefore, it is concluded that blended microspheres has greater bioavailability for pregabalin with sustained release effect. This evolved that TCM has been proved to be emerging potential pharmaceutical excipient for sustained release drug delivery systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI