分子模拟
生物
自身免疫
药物发现
结核分枝杆菌
模仿
肺结核
计算生物学
致病菌
药物重新定位
药品
微生物学
细菌
免疫学
遗传学
免疫系统
生物信息学
医学
药理学
病理
生态学
作者
Anjali Garg,Bandana Kumari,Neelja Singhal,Manish Kumar
标识
DOI:10.1016/j.drudis.2018.10.010
摘要
Several microbial pathogens cause autoimmune diseases in humans by exhibiting molecular mimicry with the host proteins. However, the contribution of autoimmunity in microbial pathogenesis has not been evaluated critically. Clinical and experimental observations have supported and corroborated that autoimmunity was a fundamental process underlying pathology of human tuberculosis bacteria. In the current review, we propose novel drug targets based on a pathogen's molecular-mimicry-inducing proteins. The process for identification of drug targets has been explained using Mycobacterium tuberculosis as a model organism. The procedure described here can be applied for repurposing other known drugs and/or discovery of novel therapeutics against other pathogenic bacteria that exhibit molecular mimicry with the host's proteins.
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