Selected psychological comorbidities in coronary heart disease: Challenges and grand opportunities.

Evidence of popular interest in the interrelationships between mind, body, and heart disease dates back to Grecian times and paved the way for modern day scientific inquiry into the relationships between psychological comorbidities in coronary heart disease.While the systematic evidence suggests an association of poor medical prognosis and lower quality of life among patients with coronary heart disease with comorbid psychological conditions, the mechanisms are less well understood.In this selective review article, the epidemiology, mechanisms, screening, and treatment recommendations for four common psychological conditions (depression, anxiety, stress, and insomnia) comorbid with coronary heart disease will be presented.We focus on the grand challenges and unprecedented opportunities for research in this area in light of the methodological and technological innovations of the 21 st century.