苯并咪唑
乙酰唑胺
碳酸酐酶
化学
碳酸酐酶Ⅰ
抗菌剂
质子核磁共振
碳-13核磁共振
元素分析
体外
抑制性突触后电位
生物活性
核化学
组合化学
立体化学
酶
生物化学
有机化学
生物
神经科学
生理学
作者
Mert Olgun Karataş,Adem Ergün
标识
DOI:10.18596/jotcsa.546960
摘要
The antimicrobial properties of silver compounds and biological properties of benzimidazole derivatives have been well known for many years. In the present study, in terms of their biological potential, six novel silver(I)-N-alkylbenzimidazole derivatives were synthesized in order to examine their carbonic anhydrase (CA) inhibitory properties. All complexes were characterized by the combination of 1H NMR, 13C NMR, mass, FT-IR spectroscopic methods and elemental analyses. The inhibitory properties of all complexes were tested on the esterase activity of human CA I and II (hCA I and hCA II). Acetazolamide was used as a standard. All complexes inhibited the hCA I and hCA II activity in the range of 27.37-29.58 µM and 20.93-27.25 µM, respectively.
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