Age Affects Clinical Management after Noncurative Endoscopic Submucosal Dissection for Early Gastric Cancer

医学 内镜黏膜下剥离术 胃肠病学 内科学 外科 逻辑回归
作者
Mitsuru Esaki,Waku Hatta,Tooru Shimosegawa,Tsuneo Oyama,Noboru Kawata,Akiko Takahashi,Shiro Oka,Shu Hoteya,Masahiro Nakagawa,Masaaki Hirano,Mitsuru Matsuda,Ken Ohnita,Ryo Shimoda,Motoyuki Yoshida,Osamu Dohi,Jun Takada,Keiko Tanaka,Shinya Yamada,Tsuyotoshi Tsuji,Hirotaka Ito,Hiroyuki Aoyagi,Takuji Gotoda
出处
期刊:Digestive Diseases [Karger Publishers]
卷期号:37 (6): 423-433 被引量:26
标识
DOI:10.1159/000499538
摘要

<b><i>Background:</i></b> Additional surgery is recommended after noncurative endoscopic submucosal dissection (ESD) for early gastric cancer due to the risk of lymph node metastasis. However, age may affect the clinical management of these patients. <b><i>Objectives:</i></b> The aim of our retrospective multicenter study was to clarify whether age affects decision-making after noncurative ESD and if the decision affects long-term outcomes. <b><i>Methods:</i></b> Age was classified as follows: non-elderly, &#x3c;70 years (<i>n</i> = 811); elderly, 70–79 years (<i>n</i>= 760); and super-elderly, ≥80 years (<i>n</i> = 398). Age associations with the selection for additional surgery were evaluated using logistic regression analysis. Long-term outcomes were also evaluated in each age group. <b><i>Results:</i></b> Age was inversely related to the rate of additional surgery, which ranged from 70.0% in the non-elderly group to 20.1% in the super-elderly group (<i>p</i> &#x3c; 0.001). On multivariate analysis, age &#x3c;70 years (versus age ≥80 years) was associated with the ­selection of additional surgery (OR 18.6). Overall survival (OS) in patients who underwent additional surgery was ­significantly higher in the non-elderly and elderly groups (<i>p</i>&#x3c; 0.001), whereas the difference was not significant in the super-elderly group (<i>p</i> = 0.23). <b><i>Conclusions:</i></b> Despite the fact that almost 80% of super-elderly patients did not undergo additional surgery, the difference of OS between patients with and without additional surgery was not significant only in patients ≥80 years. Therefore, establishment of criteria for selecting treatment methods after noncurative ESD in elderly patients is required.
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