Fatigue in Parkinson's disease: A systematic review and meta‐analysis

冷漠 萧条(经济学) 医学 荟萃分析 帕金森病 生活质量(医疗保健) 焦虑 疾病 内科学 心理干预 物理疗法 精神科 宏观经济学 护理部 经济
作者
Mattia Siciliano,Luigi Trojano,Gabriella Santangelo,Rosa De Micco,Gioacchino Tedeschi,Alessandro Tessitore
出处
期刊:Movement Disorders [Wiley]
卷期号:33 (11): 1712-1723 被引量:186
标识
DOI:10.1002/mds.27461
摘要

ABSTRACT We conducted a systematic review and meta‐analysis aimed at establishing robust prevalence estimates and identifying clinical correlates of fatigue in PD. From 2,459 titles and abstracts, we selected 44 relevant studies (n = 7427 patients). Overall, the meta‐analysis showed a prevalence of fatigue of 50% in PD. This prevalence estimate, however, was significantly moderated by study heterogeneity in measurement scales and cut‐off thresholds. In contrast, demographic features, disease severity, cognitive impairment, and depression did not moderate prevalence estimates. Moreover, fatigue prevalence did not differ between de novo and treated PD patients. Compared to nonfatigued patients, fatigued patients had sligthly higher age (1.44 years), disease duration (0.93 years), l ‐dopa equivalent daily dose (50.89 units), UPDRS‐III (4.99 points), and H & Y (0.33 points), as well as risk of comorbid depression (risk ratio = 1.89) and had a little lower MMSE score (–0.66 points). Fatigue was moderately associated with apathy (Hedges' g = 0.55), anxiety (Hedges' g = 0.67), daytime somnolence (Hedges' g = 0.43), sleep disturbances (Hedges' g = 0.66), and poorer quality of life (Hedges' g = 1.23). Our analyses suggest that fatigue is a frequent, independent nonmotor symptom in PD appearing early and persisting throughout the disease course, and that establishing uniform diagnostic criteria for PD‐related fatigue is critical. In addition, several nonmotor symptoms appear to be associated with fatigue and negatively impact quality of life. Pharmacological and nonpharmacological interventions targeting fatigue and associated symptoms may improve quality of life in patients with PD. © 2018 International Parkinson and Movement Disorder Society
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
Lucas应助Livrik采纳,获得10
2秒前
cyn0762完成签到,获得积分10
2秒前
点到为止完成签到,获得积分10
3秒前
4秒前
Akim应助lll采纳,获得10
5秒前
高贵灵槐完成签到 ,获得积分10
6秒前
9秒前
wxh完成签到 ,获得积分20
9秒前
量子星尘发布了新的文献求助10
9秒前
liuzi发布了新的文献求助20
10秒前
雨过天晴完成签到,获得积分10
11秒前
花花完成签到 ,获得积分10
12秒前
13秒前
15秒前
汪汪发布了新的文献求助10
18秒前
18秒前
19秒前
22秒前
追寻筮关注了科研通微信公众号
22秒前
miaojuly发布了新的文献求助10
23秒前
充电宝应助汪汪采纳,获得10
24秒前
25秒前
涵哈哈哈哈哈完成签到 ,获得积分10
27秒前
29秒前
liuzi完成签到,获得积分10
29秒前
科目三应助油菜的星星采纳,获得10
31秒前
31秒前
31秒前
32秒前
32秒前
木心应助高院士采纳,获得60
33秒前
33秒前
33秒前
34秒前
搜集达人应助卢敏明采纳,获得10
34秒前
林正心完成签到,获得积分10
35秒前
35秒前
35秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035