丝素
静电纺丝
膜
姜黄素
化学
纳米纤维
丝绸
化学工程
高分子化学
核化学
材料科学
复合材料
有机化学
聚合物
生物化学
工程类
作者
Xusheng Xie,Jia Yu,Zeyu Zhao,Zhaozhu Zheng,Maobin Xie,Xiaoqin Wang,Zhigang Han,Gang Li
标识
DOI:10.1177/0263617418820416
摘要
This paper describes a silk fibroin-based nanofibrous membranes loaded with antitumor drugs curcumin and 5-fluorouracil using electrospinning technique. The concentration of curcumin/5-fluorouracil in the silk fibroin solution for electrospinning was optimized to be 0.15/0.25, 0.3/0.5, and 0.45/0.75 wt%. The morphology, hydrophilic property, pore size, secondary structure, and antitumor drugs release of nanofibrous membranes were measured. The diameter of nanofibrous membranes ranged about 100–200 nm. The results indicated that electrospinning process did not influence the secondary structure and the drug content of antitumor drugs, and dual drugs encapsulated in the silk fibroin nanofibrous membranes were released in a steady and consistent process. In conclusion, the silk fibroin-based drug-loaded membranes can be useful as biomaterials with antitumor function.
科研通智能强力驱动
Strongly Powered by AbleSci AI