清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats

ATG5型 癌症 细胞凋亡 免疫印迹 自噬 胃癌 医学 黄芪 免疫组织化学 癌症研究 传统医学 胃肠病学 病理 内科学 生物 中医药 基因 生物化学 替代医学
作者
Tiantian Cai,Chengzhe Zhang,Ziming Zhao,Siyi Li,Haobin Cai,Xiaodong Chen,Dake Cai,Wei Liu,Yan Yan,Kaifeng Xie,Huafeng Pan,Xiaohui Zeng
出处
期刊:Biomedicine & Pharmacotherapy [Elsevier]
卷期号:104: 291-299 被引量:46
标识
DOI:10.1016/j.biopha.2018.04.013
摘要

Gastric Cancer is one of the most common types of cancer. And the occurrence of gastric carcinoma is an evolutionary histopathological stage. As a result, further research of GPL, which is a borderline of gastric cancer, is indispensable for preventing the formation and development of gastric carcinoma. Several studies have demonstrated a correlation between the expression of autophagy, apoptosis and Gastric cancer (GC). However, the effects of autophagy and apoptosis on human gastric cancer progression, particularly on gastric precancerous lesions (GPL), have not totally been investigated. At present, Astragaloside IV(AS-IV) is a saponin purified from Astragalus membranaceous Bge, a traditional Chinese herb that has been widely used for more than 2000 y in the treatment of cancer, cardiovascular and immune disorders. This study was designed to investigate the mechanism of AS-IV protecting gastric mucosa in N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced GPL rats. The lesions of GIM and GED were significantly ameliorated compared with the model rats, especially crowded tubular glandular and back-to-back tubular structure, which were the dangerous borderline between GPL and GC. Western Blot analysis showed that the ratio of Bcl-2/Bax and the protein expression of Bcl-XL, p53, Beclin1, p62, ATG5 and ATG12 were decreased and the level of Caspase3 was increased in the group of AS-IV compared with the model group; RT-PCR analysis showed that the gene expression Ambra1, Beclin1, ATG5, LC3 and p62 were decreased in the group of AS-IV compared with the model group. This research manifested that the occurrence of gastric cancer was preceded by a prolonged precancerous stage, which could be ameliorated by the AS-IV. Meanwhile, the mild and moderate stage of precancerous lesions is similar with gastric adenocarcinoma in critical biological processes, including inflammation, cell proliferation, differentiation. But this lesion is very different from cancer, because it does not appear obvious invasion and malignant lesions in this pathologic stag. Further, AS-IV could regulate p53 expression to activate the Ambra1/Beclin1 complex in GPL, and it will protect the gastric mucosal injury, prevent and cure gastric mucosal atrophy, intestinal metaplasia and atypical hyperplastic lesions. It provided a potential therapeutic strategy in reversing intestinal metaplasia and dysplasia of gastric precancerous lesions and protecting the gastric mucosa in GPL rats.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
4秒前
草木完成签到,获得积分10
33秒前
39秒前
慕青应助姚倩倩采纳,获得10
1分钟前
1分钟前
爱静静应助科研通管家采纳,获得10
1分钟前
爱静静应助科研通管家采纳,获得10
1分钟前
爱静静应助科研通管家采纳,获得10
1分钟前
姚倩倩发布了新的文献求助10
1分钟前
1分钟前
2分钟前
有终完成签到 ,获得积分10
2分钟前
lucky完成签到 ,获得积分10
2分钟前
清脆安南完成签到 ,获得积分10
2分钟前
2分钟前
丘比特应助姚倩倩采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
3分钟前
3分钟前
4分钟前
方白秋完成签到,获得积分10
4分钟前
believe完成签到,获得积分10
4分钟前
月儿完成签到 ,获得积分10
4分钟前
青出于蓝蔡完成签到,获得积分10
4分钟前
快乐半山发布了新的文献求助10
4分钟前
起风了完成签到 ,获得积分10
4分钟前
快乐半山完成签到,获得积分20
4分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
5分钟前
5分钟前
KIKIup发布了新的文献求助10
6分钟前
6分钟前
6分钟前
美好蜻蜓完成签到 ,获得积分10
6分钟前
7分钟前
7分钟前
李健的小迷弟应助炫白采纳,获得10
7分钟前
黑球发布了新的文献求助10
7分钟前
7分钟前
8分钟前
高分求助中
Solution Manual for Strategic Compensation A Human Resource Management Approach 1200
Natural History of Mantodea 螳螂的自然史 1000
Glucuronolactone Market Outlook Report: Industry Size, Competition, Trends and Growth Opportunities by Region, YoY Forecasts from 2024 to 2031 800
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 500
The analysis and solution of partial differential equations 400
Sociocultural theory and the teaching of second languages 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3338996
求助须知:如何正确求助?哪些是违规求助? 2967044
关于积分的说明 8627876
捐赠科研通 2646460
什么是DOI,文献DOI怎么找? 1449226
科研通“疑难数据库(出版商)”最低求助积分说明 671343
邀请新用户注册赠送积分活动 660162