脂肪酶
催化作用
化学
基质(水族馆)
肺表面活性物质
酒
有机化学
组合化学
水溶液
范围(计算机科学)
羧酸
胶束
小学(天文学)
酶
生物化学
计算机科学
生物
物理
天文
程序设计语言
生态学
作者
Vani Singhania,Margery Cortes‐Clerget,Jade Dussart‐Gautheret,Bhornrawin Akkachairin,Tzu‐Yu Yu,Nnamdi Akporji,Fabrice Gallou,Bruce H. Lipshutz
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:13 (5): 1440-1445
被引量:35
摘要
Esterification in an aqueous micellar medium is catalyzed by a commercially available lipase in the absence of any co-factors. The presence of only 2 wt% designer surfactant, TPGS-750-M, assists in a 100% selective enzymatic process in which only primary alcohols participate (in a 1 : 1 ratio with carboxylic acid). An unexpected finding is also disclosed where the simple additive, PhCF3 (1 equiv. vs. substrate), appears to significantly extend the scope of usable acid/alcohol combinations. Taken together, several chemo- and bio-catalyzed 1-pot, multi-step reactions can now be performed in water.
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