碱性成纤维细胞生长因子
血管平滑肌
细胞生物学
生物
细胞生长
成纤维细胞生长因子
细胞培养
血管
生长因子
内皮干细胞
平滑肌
内分泌学
体外
受体
生物化学
遗传学
作者
Kiyomi Tsuji‐Tamura,Masato Tamura
出处
期刊:FEBS Letters
[Wiley]
日期:2022-04-06
卷期号:596 (13): 1686-1699
被引量:4
标识
DOI:10.1002/1873-3468.14345
摘要
Blood vessels normally remain stable over the long term. However, in atherosclerosis, vascular cells leave the quiescent state and enter an activated state. Here, we investigated the factors that trigger the breakage of the quiescent state by screening growth factors and cytokines using a vascular smooth muscle cell (SMC) line and an endothelial cell (EC) line. Despite known functions of the tested factors, only basic fibroblast growth factor (bFGF) was identified as a potent trigger of quiescence breakage in SMCs, but not ECs. bFGF disrupted tight SMC‐monolayers and caused morphological changes, proliferation, and dedifferentiation. Human primary SMCs, but not ECs, also showed similar results. Aberrant SMC proliferation is a critical histological event in atherosclerosis. We, thus, provide further insights into the role of bFGF in vascular pathobiology.
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