基因沉默
癌变
下调和上调
癌症研究
恶性肿瘤
竞争性内源性RNA
细胞凋亡
肝细胞癌
TLR4型
机制(生物学)
体内
小RNA
肿瘤进展
生物
内生
化学
基因
信号转导
细胞生物学
长非编码RNA
遗传学
生物化学
哲学
认识论
作者
Xiao Fan,Fei Xu,Hua Zhang,Xiaoming Shuai
标识
DOI:10.1016/j.bbrc.2022.02.073
摘要
Cholangiocarcinoma (CCA) is the second most common liver malignancy with poor prognosis after hepatocellular carcinoma (HCC). Emerging evidences have proved that circular RNAs (circRNAs) are involved in the progression of multiple cancers, while their roles in tumorigenesis of CCA remains largely unclear. In the present study, we found circ_0000591 was upregulated in CCA cells and tissues. The highly expressed circ_0000591 could promote the proliferation, migration, invasion and carcinogenesis of CCA cells in vitro and in vivo. Functionally, circ_0000591 induced the proliferation, migration and invasion of CCA cells through sponging miR-326. Moreover, silencing of circ_0000591 attenuated LPS-induced anti-apoptosis of CCA cells through the TLR4/MyD88/IL6 pathway. In conclusion, this study revealed a novel regulatory mechanism that circ_0000591 contributed to the progression of CCA via miR-326/TLR4/MyD88/IL6 axis. These findings enhanced our knowledge of potential molecular mechanism involved in the malignant progression of CCA.
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