Influence of skeletal muscle volume loss during lenvatinib treatment on prognosis in unresectable hepatocellular carcinoma: a multicenter study in Tohoku, Japan

伦瓦提尼 医学 肝细胞癌 危险系数 肌萎缩 萎缩 内科学 胃肠病学 多元分析 泌尿科 肿瘤科 置信区间 索拉非尼
作者
Masashi Fujita,Kazumichi Abe,Hidekatsu Kuroda,Takayoshi Oikawa,Masashi Ninomiya,Atsushi Masamune,Kazuo Okumoto,Tomohiro Katsumi,Wataru Sato,Katsunori Iijima,Tetsu Endo,Shinsaku Fukuda,Nobukazu Tanabe,Hiroshi Numao,Yasuhiro Takikawa,Yoshiyuki Ueno,Hiromasa Ohira
出处
期刊:Scientific Reports [Springer Nature]
卷期号:12 (1) 被引量:7
标识
DOI:10.1038/s41598-022-10514-3
摘要

Sarcopenia is associated with poor prognosis of patients with hepatocellular carcinoma (HCC). We investigated the association of skeletal muscle volume (SMV) and its change in HCC patients taking lenvatinib. In 130 HCC patients, psoas mass index (PMI) was calculated as the left-right sum of the major × minor axis of psoas muscle at the third lumbar vertebra, divided by height squared. Patients were classified into two groups (low and normal PMI) based on indices of < 6.0 cm2/m2 for man and < 3.4 cm2/m2 for women. Change in PMI per month during the lenvatinib administration period (ΔPMI/m) was calculated; and patients were classified into two groups (severe and mild atrophy) based on the ΔPMI/m rate, as ≥ 1% or < 1%, respectively. There was no significant difference in Overall survival (OS) between the low and normal PMI groups at the start of lenvatinib administration. OS was significantly lower in the severe atrophy group than in the mild atrophy group (median; 15.2 vs. 25.6 months, P = 0.005). Multivariate analysis revealed a significant association of severe atrophy with OS (hazard ratio 1.927, P = 0.031). Progressive loss of SMV is a strong predictor of poor prognosis in HCC patients taking lenvatinib.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
taotie发布了新的文献求助20
刚刚
南楼小阁主完成签到,获得积分10
1秒前
1秒前
天天快乐应助cc采纳,获得10
1秒前
3秒前
jinan完成签到,获得积分10
4秒前
爆浆蛋卷完成签到 ,获得积分10
4秒前
4秒前
moco完成签到,获得积分10
4秒前
chao发布了新的文献求助10
5秒前
沐沐发布了新的文献求助10
5秒前
秋风今是完成签到 ,获得积分10
6秒前
6秒前
7秒前
8秒前
sdahjjyk完成签到,获得积分10
9秒前
9秒前
10秒前
只想求文献完成签到,获得积分10
10秒前
1l2kl完成签到,获得积分10
11秒前
琦琦777完成签到,获得积分10
11秒前
YY发布了新的文献求助20
12秒前
13秒前
瘦瘦发布了新的文献求助10
13秒前
菲菲菲发布了新的文献求助10
14秒前
搜集达人应助sdahjjyk采纳,获得10
14秒前
xiaoxinxin完成签到,获得积分10
14秒前
robi发布了新的文献求助10
14秒前
yn发布了新的文献求助10
15秒前
jing111完成签到,获得积分10
15秒前
16秒前
louziqi完成签到,获得积分10
18秒前
SciGPT应助xiaoxinxin采纳,获得10
18秒前
瘦瘦完成签到,获得积分10
19秒前
聂学雨发布了新的文献求助10
19秒前
19秒前
菲菲菲完成签到,获得积分20
19秒前
欢呼的时光完成签到 ,获得积分10
20秒前
21秒前
刘斌驳回了Hello应助
21秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3134791
求助须知:如何正确求助?哪些是违规求助? 2785712
关于积分的说明 7773726
捐赠科研通 2441524
什么是DOI,文献DOI怎么找? 1297985
科研通“疑难数据库(出版商)”最低求助积分说明 625075
版权声明 600825