医学
危险系数
轮班制
入射(几何)
比例危险模型
人口学
内科学
心力衰竭
置信区间
精神科
物理
社会学
光学
作者
Cheng Xu,Zhenkun Weng,Jingjia Liang,Qian Liu,Xin Zhang,Jin Xu,Qingguo Li,Yong Zhou,Aihua Gu
标识
DOI:10.1016/j.mayocp.2021.12.003
摘要
Objective To quantify the association of combined shift work and genetic factors with the incidence of heart failure (HF). Participants and Methods This study included 242,754 participants with complete shift work information in the UK Biobank. Participants were followed from baseline (2006 to 2010) through January 31, 2018. The association between shift work and HF incidence was investigated separately in males and females using a Cox proportional hazards model adjusted for covariates. In addition, we established a polygenic risk score and assessed whether shift work alters genetic susceptibility to HF. Results The results showed a significant association of permanent night shift work with incident HF among females (hazard ratio, 2.25; 95% CI, 1.34 to 3.76; P=.002) after adjusting for age, and the association was attenuated in the fully adjusted model. Among men, we did not detect an association between shift work and HF. In addition, we observed that the association between the risk of HF and shift work was strengthened by high genetic risk. Permanent night shift work paired with high genetic risk, compared with low genetic risk, was suggested to be associated with the risk of HF in females (hazard ratio, 2.89; 95% CI, 1.05 to 7.94) but not in males. Conclusion Shift work, particularly permanent night shift work, may increase the risk of HF in females, especially in those with high genetic risk.
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