坏死性下垂
急性胰腺炎
胰蛋白酶原
发病机制
医学
胰腺炎
机制(生物学)
疾病
组织蛋白酶B
程序性细胞死亡
细胞凋亡
免疫学
生物
内科学
胰蛋白酶
酶
生物化学
哲学
认识论
作者
Yujie Lin,Jihong Xiao,Xin Liu,Xiangli Ma,Chaoze Jiao,Peiwu Li
出处
期刊:PubMed
日期:2022-03-01
卷期号:34 (3): 329-332
被引量:1
标识
DOI:10.3760/cma.j.cn121430-20211125-01783
摘要
Acute pancreatitis (AP) is a common and potentially threatening disease of the pancreas, and some patients eventually develop to severe acute pancreatitis (SAP). Symptomatic support therapies such as rehydration therapy and anti-infection are still the main treatments. Lacking specific therapies is the main reason for the high mortality of AP patients, especially those with SAP. Premature trypsinogen activation is the most important pathologic cellular event in the pathogenesis of AP. The release of trypsin can cause self-digestion inside and outside of acinar cells, especially the release of cathepsin B can also cause a caspase-unrelated regulatory cell death (RCD) known as necroptosis, which is closely related to the development and prognosis of AP. Therefore, it is necessary to further study the mechanism of necroptosis in the occurrence and development of AP. This article reviews the mechanism of necroptosis and the research progress related to AP, in an attempt to provide a new understanding of the pathogenesis and treatment of AP, and promote the better target drug development.
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