Combined Association of Low-Density Lipoprotein Cholesterol Levels and Systolic Blood Pressure to the Outcome of Intracerebral Hemorrhage: Data from the China Stroke Center Alliance

医学 脑出血 血压 逻辑回归 内科学 冲程(发动机) 人口 胃肠病学 心脏病学
作者
Yarong Ding,Xuesen Zhao,Liping Liu,Hongqiu Gu,Kaixuan Yang,Zixiao Li,Xingquan Zhao
出处
期刊:Oxidative Medicine and Cellular Longevity [Hindawi Publishing Corporation]
卷期号:2022: 1-8
标识
DOI:10.1155/2022/6206315
摘要

Limited data were available about the combined impact of systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) levels on intracerebral hemorrhage (ICH) prognosis. The objective of this study is to explore whether the relationship between LDL-C and ICH outcomes was modified by SBP levels in a Chinese population. From August 1, 2015, to July 31, 2019, 75,443 ICH patients enrolled from the Chinese Stroke Center Alliance program were included in our study. Patients were divided into LDL-C levels of <70 mg/dL, 70-100 mg/dL, and ≥100 mmol/L. SBP was stratified as <140 mmHg, 140-180 mmHg, and ≥180 mmHg. The primary outcome was the occurrence of hematoma expansion (HE), and the second outcome was in-hospital mortality. Correlation between LDL-C levels and SBP on ICH outcomes were assessed by logistic regression. 6,116 (8.1%) and 1,576 (2.1%) patients suffered HE and in-hospital mortality. Compared with the ≥100 mg/dL group, patients with LDL-C concentrations under 70 mg/dL had a 19% and 24% increase in the relative risk of HE (crude OR 1.19, 95% CI 1.11-1.28) and in-hospital mortality (crude OR 1.24, 95% CI 1.08-1.42). When SBP was added as a stratification variable, the above-mentioned association was attenuated in patients under a threshold SBP of 140 mmHg ( P > 0.05 ). However, no statistical interaction was detected between SBP and LDL-C levels. Lower LDL-C levels (<70 mg/dL) are related to a higher risk of HE and in-hospital mortality confined to ICH patients with elevated SBP (≥140 mmHg).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Milktea123发布了新的文献求助10
2秒前
彭于晏应助徐志成采纳,获得10
3秒前
量子星尘发布了新的文献求助10
6秒前
Theo完成签到,获得积分10
11秒前
大气的哈密瓜完成签到,获得积分10
12秒前
12秒前
彭于晏应助victorchen采纳,获得10
13秒前
雪白卿完成签到,获得积分10
13秒前
14秒前
16秒前
Theo发布了新的文献求助10
16秒前
17秒前
w_donghui完成签到,获得积分10
20秒前
鲤鱼安青发布了新的文献求助10
21秒前
快飞飞完成签到 ,获得积分10
24秒前
叶夜南完成签到 ,获得积分10
26秒前
30秒前
WJM完成签到,获得积分10
31秒前
JAJ完成签到 ,获得积分10
33秒前
所所应助小郑采纳,获得10
34秒前
独特冰安发布了新的文献求助10
34秒前
liyuxuan发布了新的文献求助10
34秒前
35秒前
戴佳伟彩笔完成签到,获得积分10
35秒前
劉浏琉完成签到,获得积分10
37秒前
领导范儿应助勤恳紫霜采纳,获得10
37秒前
Luu完成签到 ,获得积分10
39秒前
39秒前
40秒前
灵魂发布了新的文献求助10
41秒前
高挑的若剑完成签到,获得积分10
42秒前
mt13完成签到,获得积分10
42秒前
科研通AI2S应助科研通管家采纳,获得10
43秒前
yar应助科研通管家采纳,获得10
43秒前
田様应助科研通管家采纳,获得10
43秒前
科研通AI5应助科研通管家采纳,获得10
43秒前
共享精神应助科研通管家采纳,获得10
43秒前
43秒前
Owen应助科研通管家采纳,获得10
43秒前
43秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975378
求助须知:如何正确求助?哪些是违规求助? 3519775
关于积分的说明 11199621
捐赠科研通 3256067
什么是DOI,文献DOI怎么找? 1798124
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305