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The impact of compensated and decompensated cirrhosis on the postoperative outcomes of patients undergoing hernia repair: a propensity score-matched analysis of 2011–2017 US hospital database

医学 肝硬化 腹水 失代偿 疝修补术 脐疝 内科学 置信区间 腹股沟疝 外科 胃肠病学
作者
David U. Lee,David Jeffrey Hastie,Ki Jung Lee,Gregory H. Fan,Elyse Ann Addonizio,Jean Kwon,Raffi Karagozian
出处
期刊:European Journal of Gastroenterology & Hepatology [Lippincott Williams & Wilkins]
卷期号:33 (1S): e944-e953 被引量:3
标识
DOI:10.1097/meg.0000000000002321
摘要

Background and aims Since there is clinical overlap between populations with cirrhosis and those who require hernia repair (i.e. due to stretching of abdominal walls), we systematically evaluate the effects of cirrhosis on post-hernia repair outcomes. Methods 2011–2017 National Inpatient Sample was used to identify patients who underwent hernia repair (included: inguinal, umbilical, and other abdominal hernia repairs). The population was stratified into those with compensated cirrhosis (CC), decompensated cirrhosis (DC), and no cirrhosis; hepatic decompensation was defined as those with portal hypertension, ascites, and varices. The propensity score was used to match the no-cirrhosis controls to CC and DC using the 1:1 nearest neighbor mechanism. Endpoints included mortality, length of stay, costs, and complications. Results Postmatch, there were 392/446 CC/DC with equal number controls in those undergoing inguinal hernia repair, 714/1652 CC/DC with equal number controls in those undergoing umbilical hernia repair, and 784/702 CC/DC. In multivariate, for inguinal repair, there was no difference in mortality [CC vs. no-cirrhosis aOR 2.61, 95% confidence interval (CI) 0.50–13.52; DC vs. no-cirrhosis: aOR 1.75, 95% CI 0.84–3.63]. For umbilical repair, there was no difference in mortality for CC vs. no-cirrhosis: aOR 0.94, 95% CI 0.36–2.42); however, DC had higher mortality (aOR 2.86, 95% CI 1.76–4.63) when comparing DC vs. no-cirrhosis. For other abdominal repairs, there was no difference in mortality for CC vs. no-cirrhosis (aOR 1.10, 95% CI 0.54–2.23); however, DC had higher mortality ( P < 0.001, aOR 2.58, 95% CI 1.49–4.46) when comparing DC vs. no-cirrhosis. Conclusion This study demonstrates that the presence of DC affects postoperative survival in patients undergoing umbilical or other abdominal hernia repair surgery.
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