Pretreatment with curcumin attenuates anxiety while strengthens memory performance after one short stress experience in male rats

姜黄素 高架加迷宫 谷胱甘肽过氧化物酶 丙二醛 抗焦虑药 莫里斯水上航行任务 焦虑症 超氧化物歧化酶 行为绝望测验 药理学 低能 阿切 神经化学 抗氧化剂 氧化应激 医学 乙酰胆碱酯酶 心理学 抗抑郁药 焦虑 内科学 化学 海马体 生物化学 精神科
作者
Saida Haider,Farwa Naqvi,Zehra Batool,Saiqa Tabassum,Sadia Sadir,Laraib Liaquat,Faizan Naqvi,Nudrat Anwer Zuberi,Hina Shakeel,Tahira Perveen
出处
期刊:Brain Research Bulletin [Elsevier]
卷期号:115: 1-8 被引量:58
标识
DOI:10.1016/j.brainresbull.2015.04.001
摘要

It is observed that memories are more strengthened in a stressful condition. Studies have also demonstrated an association between stressful events and the onset of depression and anxiety. Considering the nootropic, anxiolytic and antidepressant-like properties of curcumin in various experimental approaches, we appraised the beneficial effects of this herb on acute immobilization stress-induced behavioral and neurochemical alterations. Rats in test group were administrated with curcumin (200mg/kg/day), dissolved in neutral oil, for 1 week. Both control and curcumin-treated rats were divided into unstressed and stressed groups. Rats in the stressed group were subjected to immobilization stress for 2h. After stress, the animals were subjected to behavioral tests. Immobilization stress induced an anxiogenic behavior in rats subjected to elevated plus maze test (EPM). Locomotor activity was also significantly increased following the acute immobilization stress. Pre-administration of curcumin prevented the stress-induced behavioral deficits. Highest memory performance was observed in stressed rats that were pre-treated with curcumin in Morris water maze (MWM). Brain malondialdehyde (MDA) levels, catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), and acetylcholinesterase (AChE) activities were also estimated. Present study suggests a role of antioxidant enzymes in the attenuation of acute stress induced anxiety by curcumin. The findings therefore suggest that supplementation of curcumin may be beneficial in the treatment of acute stress induced anxiety and enhancement of memory function.
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